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Accelerated Theta Burst in Treatment-Resistant Depression: A Dose Finding and Biomarker Study
Sponsor: Stanford University
Summary
This study evaluates the effectiveness of re-treatment using accelerated schedule of intermittent theta-burst stimulation for treatment-resistant depression. This is an open label study.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2018-04-13
Completion Date
2024-12-02
Last Updated
2026-04-21
Healthy Volunteers
No
Conditions
Interventions
Intermittent theta-burst stimulation (iTBS) delivered to the L-DLPFC
Participants will receive iTBS to the left DLPFC and will be targeted utilizing either Localite's neuronavigation system or Nexstim's eField neuronavigation system. Stimulation intensity will be standardized at 90% of RMT and adjusted to the skull to cortical surface distance (see Nahas 2004). Stimulation will be delivered to the L-DLPFC or bilateral DLPFC using either a MagVenture MagPro X100 or a Nexstim TMS device.
Intermittent theta-burst stimulation (iTBS) delivered to the bilateral DLPFC
Participants will receive iTBS to bilateral DLPFC. The DLPFC will be targeted utilizing either Localite's neuronavigation system or Nexstim's eField neuronavigation system. Stimulation intensity will be standardized at 90% of RMT and adjusted to the skull to cortical surface distance (see Nahas 2004). Stimulation will be delivered to the L-DLPFC or bilateral DLPFC using either a MagVenture MagPro X100 or a Nexstim TMS device.
Locations (1)
Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine
Palo Alto, California, United States