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RECRUITING
NCT03681275
PHASE2

Janus Kinase Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction

Sponsor: Stanford University

View on ClinicalTrials.gov

Summary

We intend, with this study, to prove that blocking the molecular mechanisms whose blockade prevents VIDD in animals, will indeed prevent the development of VIDD in humans as well. We believe that this evidence will serve as the required basis for proceeding with large, ICU-based clinical trial(s) of a drug to prevent VIDD.

Official title: A Clinical Trial of JAK Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

70

Start Date

2019-09-03

Completion Date

2026-11-30

Last Updated

2024-11-25

Healthy Volunteers

No

Interventions

DRUG

Tofacitinib 10 MG [Xeljanz]

administered twice daily for two days

DRUG

Placebo to match Tofacitinib

administered twice daily for two days

Locations (1)

Stanford University Medical Center

Stanford, California, United States