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Janus Kinase Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction
Sponsor: Stanford University
Summary
We intend, with this study, to prove that blocking the molecular mechanisms whose blockade prevents VIDD in animals, will indeed prevent the development of VIDD in humans as well. We believe that this evidence will serve as the required basis for proceeding with large, ICU-based clinical trial(s) of a drug to prevent VIDD.
Official title: A Clinical Trial of JAK Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2019-09-03
Completion Date
2026-11-30
Last Updated
2024-11-25
Healthy Volunteers
No
Conditions
Interventions
Tofacitinib 10 MG [Xeljanz]
administered twice daily for two days
Placebo to match Tofacitinib
administered twice daily for two days
Locations (1)
Stanford University Medical Center
Stanford, California, United States