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Reversal of Atrial Substrate to Prevent Atrial
Sponsor: Nova Scotia Health Authority
Summary
A multi-center, randomized trial to examine the effect of aggressive risk factor control and arrhythmia trigger-based intervention on recurrence of atrial fibrillation.
Official title: Reversal of Atrial Substrate to Prevent Atrial Fibrillation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
509
Start Date
2019-07-01
Completion Date
2027-12-31
Last Updated
2026-02-17
Healthy Volunteers
No
Conditions
Interventions
Aggressive Risk Factor Control
1. Sleep apnea screening, therapy is recommended if apopnea-hypopnea (AHI) index is greater than 15, with a target index of less than 5. 2. Counseling regarding alcohol reduction to 2 drinks/day for men, 1 drink/day for women, no binge drinking (\>5 drinks at one setting). 3. Participation in a 12 week structured, home-based exercise program and nutritional counseling. Weight reduction will be emphasized through modification of diet and exercise. 4. Blood Pressure management to achieve a target systolic blood pressure (SBP) of \<120/80 mm/Hg 5. Smoking cessation facilitated through local resources already established at each site
Standard of Care
Recommendations based on current guidelines
Locations (17)
Foothills Hospital
Calgary, Alberta, Canada
Mazankowski Alberta Heart Institute
Edmonton, Alberta, Canada
Kelowna General Health
Kelowna, British Columbia, Canada
St. Paul's Hospital
Vancouver, British Columbia, Canada
Saint John Regional Hospital
Saint John, New Brunswick, Canada
QE II Health Sciences Centre
Halifax, Nova Scotia, Canada
Hamilton Health Sciences Center
Hamilton, Ontario, Canada
St. Mary's General Hospital
Kitchener, Ontario, Canada
London Health Sciences Center
London, Ontario, Canada
Ottawa Heart Institute
Ottawa, Ontario, Canada
St. Michael's Hospital
Toronto, Ontario, Canada
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
Laval Hospital
Laval, Quebec, Canada
McGill University Health Centre
Montreal, Quebec, Canada
Montreal Heart Institute
Montreal, Quebec, Canada
Sacre Coeur Hospital
Montreal, Quebec, Canada
Regina General Hospital
Regina, Saskatchewan, Canada