Clinical Research Directory

Inclusion Criteria: * Men and women older than 18 years-old; * Suffering from a Mood Depressive Episode ( according to DSM IV criteria), and-or Mood Depressive recurrent depression (unipolar or bipolar) (\<at stage 3 of Thase and Rush). Treatment resistance will be assessed using Thase an Rush Classification and measured with Maudsley Staging Method (Fekadu et al., 2009); * MADRS score 15; * Capacity for the patient to receive information on protocol; * Patient who gave their consent to the protocol. Exclusion Criteria: * Contra-indication to MRI * Patients under social protection or hospitalized without their consent * Patients suffering from a psychiatric comorbidity such as: schizophrenia, schizo-affective disorder, personality disorder, actual addiction, anorexia-bulimia, obsessive-compulsive disorder; * Patients suffering from severe intercurrent disease with health prognosis engaged; * Patients suffering from neurological comorbidity such as: any neurodegenerative disorder (Alzheimer disease, Parkinson disease, Lewy's body disease, multiple sclerosis), any intracranial expansive process. * Patients with an history of severe cranial injury (with coma); * Patients with abnormal cerebral MRI.