Clinical Research Directory

Inclusion Criteria: * \- PATIENTS: * Men and Women, * Age 18-60 years, * Native French language, * Clinically isolated neurological syndrome (CIS) compatible with a demyelinating inflammatory episode within the central nervous system, potentially beginning multiple sclerosis (MS) whatever the mode of presentation, * Between 60 and 180 days from the onset, * At least two clinically silent lesions on their T2-weighted brain or spinal MRI scan with a size of least 3 mm, at least one of which being cerebral, ovoid, or periventricular, * Willing to participate and to sign informed consent. * \- HEALTHY CONTROLS * Men and Women, * Age 18-60years, * Native French language, * Willing to participate and to sign informed consent. Exclusion Criteria: * \- PATIENTS: * Prior documented neurological episode suggestive of MS, * History of neurological disease and/or other neurological diseases, * Psychiatric diseases, * Known chronic systemic diseases as judged by the investigator, * Alcohol or other addiction to toxic, * Disabling visual or motor problems preventing participation to neuropsychological assessments, * Acquisition disorders : Dyslexia, Dysphasia, Dyscalculia and dyspraxia, * Dosage change, stop or start of hypnotic or anxiolytic or antidepressive treatment less than 30 days, * Contra-indication to MRI (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body, claustrophobia), * Steroid treatment less than one month (be taken orally or by infusion) at the dosage of 500mg daily, * Illiteracy, is unable to count or to read, * Pregnant or breastfeeding women, * Patient concerned by articles L 1121-5 to L 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent). * \- HEALTHY CONTROLS * History of neurological disease and/or neurological diseases, * Psychiatric diseases, * Known chronic systemic diseases as judged by the investigator, * Alcohol or other addiction to toxic, * Acquisition disorders: Dyslexia, Dysphasia, Dyscalculia and dyspraxia, * Known cognitive impairment or Prior neuropsychological testing with the same tests less than one year, * Hypnotic or anxiolytic or antidepressive treatment, * Steroid treatment less than one month (be taken orally or by infusion) at the dosage of 500mg daily, * Contra-indication to MRI (pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body, claustrophobia) or refusing MRI, * Illiteracy, unable to count or to read, * Pregnant or breastfeeding women, * Patient concerned by articles L 1121-5 to L 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent).