Clinical Research Directory

Inclusion Criteria: 1. Preterm infant ≤27 6/7 2. Written parental consent is obtained 3. Infant requires respiratory support 4. diagnosis of a persistent patent ductus arteriosus after 5 days of age, (defined as at least two of the following: 1. Ductus size ≥ 1.5 mm 2. Maximum flow velocity through the ductus ≤ 2 m/s 3. Left atrium to aorta ratio ≥ 1.4 4. Wide pulse pressure 5. B-type natriuretic peptide (BNP) 5. Attending neonatologist made decision to treat patent ductus arteriosus Exclusion Criteria: 1. No parental consent 2. Infants \> 21days of postnatal age 3. Congenital anomalies such as cardiac or multiple anomalies 4. Infection (e.g., septicemia, pneumonia) 5. Bleeding disorder or platelet count\< 50,000/ml 6. Acute kidney injury (AKI)defined as oliguria (urine output\< 0.5 ml/kg/hr for 16hrs) and/or serum creatinine \> 1.5 mg/dl 7. Elevated liver enzymes (\>2 fold from upper normal limits) 8. Pulmonary hypertension or right to left shunt through the ductus arteriosus 9. Diagnosis of necrotizing enterocolitis 10. Unable to tolerate oral medications at the time of enrollment.