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The Bern Heart and Brain Interaction Study - Interaction Between Brain and Heart in Acute Ischemic Stroke
Sponsor: Insel Gruppe AG, University Hospital Bern
Summary
Acute ischemic stroke is caused by blockage of blood vessels in the brain. Blood vessels can be obstructed by several different mechanisms and identification of this cause is essential to minimize the risk of recurrence.
Key Details
Gender
All
Age Range
18 Years - 86 Years
Study Type
OBSERVATIONAL
Enrollment
220
Start Date
2018-12-01
Completion Date
2026-12-31
Last Updated
2024-11-22
Healthy Volunteers
No
Conditions
Interventions
Short cardiovascular MRI (CMR)
A short CMR without additional contrast administration will be performed immediately after the routine brain MRI (at admission or after 24h).
Adenosine-perfusion cardiovascular MRI (CMR)
An adenosine-perfusion CMR using contrast medium (gadolinium) will be performed in all patients (except group 1) between 48h and 6 days after admission.
Blood draw
The following study-specific parameters will be tested: neuropeptide Y 1-36, neuropeptide Y 3-36, total plasma metanephrines, metabolomics analysis Time points for blood draw: at admission (routine), 3h (routine), 24h (routine), 48h, 72h and 3 months.
Urine (collection over 24h)
The following study-specific parameters will be tested: catecholamines. Time points for collection: at 24h, 72h, and 3 months
Locations (1)
Bern University Hospital - Inselspital
Bern, Canton of Bern, Switzerland