Clinical Research Directory

Inclusion Criteria: * Major patient (age ≥ 18 years) * Patient undergoing cardiac surgery under extracorporeal circulation (duration of planned CEC \> 1h) * Informed person, having read and signed his consent preoperatively no later than the day before the procedure. * Person affiliated with a social security scheme * Effective contraception in women of childbearing potential. For menopausal women, the diagnosis of menopause will be based on the gynecological history of the patient (age\> 50 years + amenorrhea for more than 12 months). Exclusion Criteria: * Patient with urgent cardiac surgery * Patient with cardiac surgery without extracorporeal circulation * Patient with surgery under "mini-CEC" * Patient with simple aortic valve replacement or single / double coronary artery bypass (CEC duration typically \<1h) * Patient with chronic autoimmune inflammatory disease, eg lupus, rheumatoid arthritis, inflammatory bowel disease ... * Patient with progressive neoplastic disease * Patient with underlying heart disease with left ventricular ejection fraction \<30% * Pregnant or lactating woman * Person deprived of liberty by an administrative or judicial decision or protected major subject (under tutorship or curatorship) * Patient participating in another interventional clinical trial