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Identification of Allergen-reactive Antibodies in the Blood of Pollen Allergic Patients
Sponsor: Mabylon AG
Summary
The project examines the hypothesis that monoclonal allergen-neutralizing antibodies can be recombinantly produced from B lymphocytes isolated from pollen allergic patients. Patient samples suitable for antibody cloning are selected based on seroprofiling for the respective allergens. The study aims at isolating lymphocytes from patients with potential allergen-neutralizing IgG in serum and to clone antibodies from antibody gene sequences obtained from B cells of those patients.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2018-10-01
Completion Date
2025-12-31
Last Updated
2025-05-02
Healthy Volunteers
Yes
Conditions
Interventions
blood withdrawal
Blood withdrawal
Locations (1)
Immunologie Zentrum Zürich
Zurich, Canton of Zurich, Switzerland