Clinical Research Directory

Inclusion Criteria: 1. documented HIV positive 2. Aged \>18 years 3. ARV naïve (previous exposure to ARV for \< 2 weeks) 4. Any CD4 cell count 5. ALT \<5 times ULN 6. estimated GFR\>60 ml/min/1.73m2 7. Hemoglobin \>7 mg/L 8. TB is diagnosed and there is a plan to receive stable doses of RIF containing anti-TB therapy for at least another 4 week period after initiation of ART 9. No other active OI (CDC class C event) except oral candidiasis or disseminated MAC 10. Body weight \>40kg 11. Able to provide written informed consent Exclusion Criteria: 1. Have documented history of HIV treatment failure or HIV mutation to NRTI, NNRTI, and/or INIs 2. Have previously treated for tuberculosis 3. Currently using immunosuppressive agents. 4. Currently using any prohibited medications that can affect the pharmacokinetics of the study drug such as phenobarbital, and carbamazepine 5. Currently using alcohol or illicit substances that may affect the conduct of the trial as per the opinion of the site Principal Investigator 6. Unlikely to be able to remain in the follow-up period as defined by the protocol 7. Patients with proven or suspected acute hepatitis. Patients with chronic viral hepatitis are eligible provided ALT, AST \< 5 x ULN. 8. Have Karnofsky performance score \<30% 9. Have TB meningitis, bone/joints (due to prolonged use of anti-TB drug) 10. Pregnant or breastfeeding