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A Pragmatic Assessment of Influenza Vaccine Effectiveness in the DoD
Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine
Summary
A total of 18,000 eligible subjects (or 6,000 subject distributed evenly between the 3 study arms) will be enrolled. Eligible subjects will be randomized in 1:1:1 (cell-culture-based vaccine, the recombinant vaccine, or the egg-based vaccine) over four influenza seasons (2018-2019, 2019-2020, 2020-2021, and 2021-2022).
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
15448
Start Date
2018-11-06
Completion Date
2026-06-30
Last Updated
2026-04-02
Healthy Volunteers
Yes
Interventions
Egg based influenza vaccines
Participants will be randomly allocated to one of three vaccine types in accordance with standard clinical practices for those in the US military. All vaccines are FDA licensed for use in the United States.
Recombinant influenza vaccines
Participants will be randomly allocated to one of three vaccine types in accordance with standard clinical practices for those in the US military. All vaccines are FDA licensed for use in the United States.
Cell-culture based influenza vaccines
Participants will be randomly allocated to one of three vaccine types in accordance with standard clinical practices for those in the US military. All vaccines are FDA licensed for use in the United States.
Locations (9)
Naval Medical Center San Diego
San Diego, California, United States
United States Naval Academy
Annapolis, Maryland, United States
USU
Bethesda, Maryland, United States
Walter Reed National Military Medical Center
Bethesda, Maryland, United States
Womack Army Medical Center
Fort Bragg, North Carolina, United States
Brooke Army Medical Center
Fort Sam Houston, Texas, United States
Lackland Airforce Base
San Antonio, Texas, United States
Naval Medical Center Portsmouth
Portsmouth, Virginia, United States
Madigan Army Medical Center
Tacoma, Washington, United States