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ACTIVE NOT RECRUITING
NCT03737214
PHASE3

A Study to Evaluate the Long-term Safety and Tolerability of Lucerastat in Adult Subjects With Fabry Disease

Sponsor: Idorsia Pharmaceuticals Ltd.

View on ClinicalTrials.gov

Summary

A study to determine the long-term safety and tolerability of oral lucerastat in adult subjects with Fabry disease. This study includes a sub-study evaluating kidney Gb3 inclusions (and other histologic lesions) in male participants with classic Fabry disease who have been treated for at least 2 years with lucerastat monotherapy in study ID-069A302.

Official title: A Multi-center, Open-label, Uncontrolled, Single-arm, Extension Study to Determine the Long-term Safety and Tolerability of Oral Lucerastat in Adult Subjects With Fabry Disease

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

107

Start Date

2018-12-18

Completion Date

2029-11

Last Updated

2025-10-21

Healthy Volunteers

No

Conditions

Interventions

DRUG

Lucerastat

Administered in hard gelatin capsules containing 250 mg of lucerastat.

Locations (42)

University of Alabama at Birmingham - Nephrology Research Clinic

Birmingham, Alabama, United States

University of California Irvine

Irvine, California, United States

UCSF Benioff Children's Hospital Oakland

Oakland, California, United States

University of Florida Clinical and Translational Science Institute, UF Clinical Research Center

Gainesville, Florida, United States

Rush University Medical Center - Dept of Pediatrics

Chicago, Illinois, United States

University of Iowa Stead Family Children's Hospital - Division of Medical Genetics

Iowa City, Iowa, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

Infusion Associates

Grand Rapids, Michigan, United States

University of Pennsylvania - Dept of Medicine

Philadelphia, Pennsylvania, United States

Greenwood Genetics Center

Greenville, South Carolina, United States

Renal Disease Research Institute LLC

Dallas, Texas, United States

Baylore University Medical Center

Dallas, Texas, United States

University of Utah - Division of Medical Genetics, Clinical Genetics Research

Salt Lake City, Utah, United States

Lysosomal and Rare Disorders Research and Treatment Center, Inc.

Fairfax, Virginia, United States

Royal Perth Hospital, Department of Nephrology

Perth, Perth, Australia

Royal Melbourne Hospital - Department of Nephrology

Parkville, Australia

Medizinische Universität Wien, Universitätsklinik für Innere Medizin III, Klinische Abteilung für Nephrologie und Dialyse

Vienna, Austria

University Hospital Ghent (UZ Ghent)

Ghent, Belgium

University Hospital Gasthuisberg, Leuven (UZ Leuven)

Leuven, Belgium

University of Calgary - Heritage Medical Research Clinic

Calgary, Canada

London Health Sciences CTR, Victoria Hospital

London, Canada

Research Center, Hôpital du Sacré-Coeur de Montréal

Montreal, Canada

Vancouver General Hospital - Adult Metabolic Diseases Clinic

Vancouver, Canada

Children's Hospital Research Institute of Manitoba

Winnipeg, Canada

Raymond Poincaré Hosp - Med Genetics Dept

Garches, France

Universitätsmedizin Berlin - Charité Campus Mitte

Berlin, Germany

SphinCS GmbH

Höchheim, Germany

Nephrologicum Markgräflerland MVZ GmbH

Müllheim, Germany

Universitätsklinikum Würzburg

Würzburg, Germany

Hospital Academisch Medisch Centrum - Department of Internal Medicine, Div. Endrocrinology and Metabolism

Amsterdam, Netherlands

Haukeland University Hospital

Bergen, Norway

Clinic of Immunological Diseases and Blood Coagulability Cracow University Hospital

Krakow, Poland

Narodowy Instytut Kardiologii Stefana kardynała Wyszyńskiego - Państwowy Instytut Badawczy

Warsaw, Poland

The Children's Memorial Health Institute, Department of Pediatric, Nutrition and Metabolic Diseases

Warsaw, Poland

Vall d'Hebron University Hospital - Unit of Inherited Metabolic Disorders and Rare Diseases

Barcelona, Spain

Hospital Universitari de Bellvitge / Nephrology Dpt

Barcelona, Spain

Hospital Universitario Ramon y Cajal. Servicio de Medicina Interna

Madrid, Spain

Hospital Quironsalud Zaragoza

Zaragoza, Spain

Psychiatrische Universitätsklinik Zürich

Zurich, Switzerland

Royal Free London NHS Foundation Trust Lysosomal Storage Disorder Unit; Department of Hematology

London, United Kingdom

National Hospital for Neurology and Neurosurgery

London, United Kingdom

Salford Hospital

Manchester, United Kingdom