Clinical Research Directory

Inclusion Criteria: 1. Respiratory failure: * Mechanical Ventilation via endotracheal tube/tracheostomy ≥ 24hrs * continuous positive airway pressure (CPAP), bilevel positive airway pressure (BIPAP) ≥ 24 consecutive hrs (provided for acute respiratory failure not for Obstructive Sleep Apnea or other stable use) * High flow nasal cannula ≥ 24 consecutive hrs (FIO2 ≥ 0.5 and flow rate ≥ 30 L/min) 2. Expected to be discharged home alive 3. Within the pandemic expansion cohort, COVID-19 status (defined as a positive result on an appropriately validated molecular diagnostic assay for infection with SARS-CoV-2) will be used to guide enrollment Exclusion Criteria: * Lack of informed consent * Patient in the ICU \< 24hrs * Mechanical ventilation at baseline * Residing at a medical institution at the time of hospital admission * Homelessness * Primary residence not in USA * Prisoner * More than mild dementia (either known diagnosis of moderate or worse dementia or Informant Questionnaire on Cognitive Decline in the Elderly (IQ-CODE) \> 3.6; screening performed on patient \> 50 years old or with family reports of possible memory decline) * Patient on hospice at or before time of enrollment * Patients who, based solely on pre-existing medical problems (such as poorly controlled neoplasm or other end-stage disease, including Stage IV heart failure or severe burns), would not be expected to survive six months in the absence of the acute respiratory failure. * Patient with neurological injury either receiving treatment for intracranial hypertension or who are not expected to return to consciousness. * Unable to communicate by telephone in English or Spanish * Patients mechanically ventilated solely for airway protection or obstruction