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ACTIVE NOT RECRUITING
NCT03740126
NA

Surveillance With PET/CT and Liquid Biopsies of Stage I-III Lung Cancer Patients After Completion of Definitive Therapy

Sponsor: Rigshospitalet, Denmark

View on ClinicalTrials.gov

Summary

The purpose of this study is to improve early detection of treatable relapse of lung cancer and thereby improve survival and quality of life for the patients. The investigators will perform a multicenter, randomized controlled trial to 1) assess if surveillance with whole body Positron Emission Tomography combined with Computer Tomography (PET/CT) including the brain can increase the number of treatable relapses and 2) concurrently collect liquid biopsies for later analysis, potentially enabling even earlier and minimally invasive detection and characterization of relapse.

Official title: Surveillance With PET/CT and Liquid Biopsies of Stage I-III Lung Cancer Patients After Completion of Definitive Therapy; a Randomized Controlled Trial

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

750

Start Date

2018-10-25

Completion Date

2026-08

Last Updated

2024-08-09

Healthy Volunteers

No

Interventions

DIAGNOSTIC_TEST

Whole body 18F-FDG PET/CT

In the experimental arm (A), an FDG-PET/CT scan will replace the CT-scan at 6, 12, 18 and 24 months post-treatment. A standard CT-scan will be performed at 3, 9, 15 and 21 months post-treatment. All patients will be asked for a blood sample for liquid biopsy and to fill in a quality of life questionnaire, concurrently every 3 months.

Locations (3)

Rigshospitalet

Copenhagen, Denmark

Gentofte Hospital

Gentofte Municipality, Denmark

Herlev Hospital

Herlev, Denmark