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Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.
Sponsor: University of Alabama at Birmingham
Summary
The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical \[F-18\]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with neuroinflammation. The PET tracer \[F-18\]DPA-714 binds to the 18 kDa translocator protein (TSPO, also known as the peripheral benzodiazepine receptor) in the mitochondria of activated microglia/macrophages and provides a non-invasive measure of neuroinflammation. The primary objective of this study is to determine if pain and fatigue patients have higher levels of neuroinflammation than HC individuals as measured with \[F-18\]DPA-714-PET/MRI.
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2019-02-03
Completion Date
2028-04
Last Updated
2026-02-20
Healthy Volunteers
Yes
Interventions
DPA-714 PET/MRI
DPA-714 PET/MRI
Locations (1)
University of Alabama at Birmingham Medical Center
Birmingham, Alabama, United States