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Additional Treatments to the Local Tumour for Metastatic Prostate Cancer: Assessment of Novel Treatment Algorithms
Sponsor: Imperial College London
Summary
Local cytoreductive treatments for men with newly diagnosed metastatic prostate cancer in addition to standard of care treatment
Official title: Local Cytoreductive Treatments for Men With Newly Diagnosed Metastatic Prostate Cancer in Addition to Standard of Care Treatment
Key Details
Gender
MALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
433
Start Date
2019-04-10
Completion Date
2027-01-31
Last Updated
2025-02-07
Healthy Volunteers
No
Interventions
Standard of Care
Androgen deprivation with or without docetaxel chemotherapy, Abiraterone, Enzalutamide or any other proven agent) treatment as determined by treating physician (positive control).
Minimally Invasive Ablative Therapy (MIAT)
MIAT includes High intensity focused ultrasound (HIFU) or Cryotherapy to the prostate. Metastatic Directed Therapy available for use.
Radical Therapy (Prostatectomy or Radiotherapy)
Radical therapy includes: Prostatectomy (any surgical approach) or External beam radiotherapy (High dose). Metastatic Directed Therapy available for use.
Locations (21)
Wirral University Teaching Hospital, Wirral University Teaching Hospital NHS Foundation Trust
Birkenhead, United Kingdom
Glan Clwyd Hospital
Bodelwyddan, United Kingdom
Darent Valley Hospital
Dartford, United Kingdom
Royal Devon and Exeter NHS Trust
Exeter, United Kingdom
Buckinghamshire Healthcare NHS Trust
High Wycombe, United Kingdom
West Middlesex University Hospital
Isleworth, United Kingdom
Queen Elizabeth Hospital, Kings Lynn
Kings Lynn, United Kingdom
Chelsea and Westminster Hospital
London, United Kingdom
The Royal Marsden NHS Foundation Trust, Chelsea Research Centre
London, United Kingdom
Imperial College Healthcare NHS Trust
London, United Kingdom
North Middlesex University Hospital
London, United Kingdom
Northwick Park, London North West Healthcare NHS Trust
London, United Kingdom
St George's University Hospital
London, United Kingdom
University College London Hospital
London, United Kingdom
Clatterbridge Cancer Centre
Metropolitan Borough of Wirral, United Kingdom
Freeman Hospital, Newcastle, Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle, United Kingdom
Oxford University Hospital
Oxford, United Kingdom
Southampton General Hospital, University Hospital Southampton NHS Foundation Trust (UHS)
Southampton, United Kingdom
Sunderland Royal Hospital, City Hospitals Sunderland NHS Foundation Trust
Sunderland, United Kingdom
Croydon University Hospital
Thornton Heath, United Kingdom
Southend University Hospital
Westcliff-on-Sea, United Kingdom