Clinical Research Directory

Inclusion Criteria: * Male or Female over 18 years-old * Patient with serious brain damages * Medical decision of withdrawing life sustaining treatment * Signed and dated informed consent by trusted person, or family * Patient covered by social security regimen * Patient eligible for organ donation according to organ donation hospital co-ordination * Glasgow Coma Scale (GCS) : * Seriously brain-injured patient without confounding factors, head trauma, brain anoxia or ischemic stroke : GCS\<5 and loss of bilateral corneal reflex or GCS\<5 and loss of three brain stem reflexes * Seriously brain-injured patient with confounding factors and without head trauma, brain anoxia or ischemic stroke : at least one of the following scanographic sign of gravity : deletion of subarachnoid cisterns, more than 15 mm deviation of the median line, hematoma volume \> 65 cm3 or hydrocephalus due to intra-ventricular bleeding with V3 or V4 flood, and, if documented, a GCS\<7. * Patient with head trauma, brain anoxia or ischemic stroke, reliable clinical examination required (no confounding factor) : GCS\<5 and loss of bilateral corneal reflex or GCS\<5 and loss of three brain stem reflexes Exclusion Criteria: * No trusted person or family present * Seriously brain-injured patient because of head trauma, brain anoxia or ischemic stroke with confounding factors * Absolute contraindication to organ donation known at the moment of inclusion (HIV, rabies, active cancer, active tuberculosis, Creutzfeldt-Jakob disease)