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Screening and Stimulation Testing for Residual Secretion of Adrenal Steroid Hormones in Autoimmune Addison's Disease
Sponsor: University of Bergen
Summary
In autoimmune adrenal insufficiency, or Addison's disease (AD), the immune system attacks the adrenal cortex. As a result, the adrenal cells producing hormones such as cortisol and aldosterone are destroyed, leaving the body with insufficient levels to meet its needs. The common perception is that upon diagnosis of Addison's disease, basically all adrenal hormone production has ceased. There have, however, been found a few individuals who preserve some residual secretion of cortisol even years after diagnosis. The objectives of this study is to find out how common it is, and to explore if residual function have impact on patient outcome. That is, do patients with and without residual function differ when it comes to quality of life, working ability, medication dosages, and risk of adrenal crisis?
Official title: Residual Secretion of Adrenal Steroid Hormones in Addison's Disease
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2018-09-26
Completion Date
2029-12-31
Last Updated
2026-05-08
Healthy Volunteers
No
Conditions
Interventions
Cosyntropin stimulation test
Blood samples are taken before (0 min), and 30 and 60 min after intravenously administration of 250 µg cosyntropin (tetracosactide acetate) with the patient placed in the recumbent position. The test will be performed non-fasting (but medication-fasting) between 08:00 and 10:00 a.m.
Baseline blood tests
Medication-fasting morning levels of adrenocortical hormones.
30-hour ambulatory sampling of intestinal fluid
30-hour ambulatory sampling of intestinal fluid for analysis of adrenocortical hormones.
Blood test
Cardiovascular and inflammatory biomarker profiles
Locations (3)
Endokrinologie in Charlottenburg
Berlin, State of Berlin, Germany
Haukeland University Hospital
Bergen, Bergen, Norway
Karolinska Institutet
Stockholm, Stockholm County, Sweden