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Phenotypic and Functional Study of 4BL B Cells in Multiple Sclerosis (MS)
Sponsor: University Hospital, Lille
Summary
Recent works highlight the B cells involvement in multiple sclerosis (MS) pathology but their role remains poorly understood. It was previously described that activated memory B cells called 4BL due to the increased expression of 4-1BBL, an activation marker, induce pro-inflammatory response by activating T CD8+ lymphocytes. Those 4BL cells are also described in systemic inflammation in 80 years old people explaining the poor efficiency of vaccination in that sub population. Those 4BL cells can also induce anti-tumoral T cell response. The hypothesize is that 4BL may induce a pathogenic inflammatory response in MS.
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
OBSERVATIONAL
Enrollment
125
Start Date
2017-07-24
Completion Date
2017-08-24
Last Updated
2026-05-05
Healthy Volunteers
Yes
Conditions
Locations (1)
chu de Lille
Lille, France