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A Prospective Evaluation of the Peri-operative Hypoxia in Breast Cancer
Sponsor: Tata Memorial Hospital
Summary
To understand the effects induced by acute hypoxia that sets in during surgery in breast cancer. To study this, clinical samples (Tumor biopsies) will be obtained during the surgery after partial devascularisation (sample B) and stored for future genomic and proteonomic evaluations.
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
500
Start Date
2017-11-27
Completion Date
2025-11-30
Last Updated
2025-09-10
Healthy Volunteers
No
Conditions
Interventions
Intra-operative Tumor Tissue Biopsy
The changing pattern of gene expression during surgery has never been studied. This could be an effect of acute hypoxia that sets in the tumour during surgery or could be a surgical response. To study these changes happening in the tumour during surgery, we are taking serial biopsies during surgery, one at the beginning, one midway during surgery and one at the end of surgery. These samples will be snap frozen and stored at -80 deg celsius in biorepository for future analysis.
Locations (1)
Tata Memorial Center
Mumbai, Maharashtra, India