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ENROLLING BY INVITATION
NCT03802799
PHASE2/PHASE3

Open Label Extension to Assess the Long-Term Safety and Tolerability of ZYN002 in Children and Adolescents With FXS

Sponsor: Zynerba Pharmaceuticals, Inc.

View on ClinicalTrials.gov

Summary

ZYN002 is a pharmaceutically manufactured Cannabidiol that is developed as a clear gel that can be applied to the skin (called transdermal delivery). The gel will be applied to clean, dry, intact skin of the shoulders and/or upper arms. Participants from the ZYN2-CL-016 and ZYN2-CL-033 studies who meet the inclusion criteria and none of the exclusion criteria for study ZYN2-CL-017 are eligible. Parents/caregivers will apply the study gel twice daily for the 52-week treatment period.

Official title: An Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of ZYN002 Administered as a Transdermal Gel to Children, Adolescents, and Young Adults With Fragile X Syndrome

Key Details

Gender

All

Age Range

3 Years - 29 Years

Study Type

INTERVENTIONAL

Enrollment

550

Start Date

2018-11-09

Completion Date

2027-08-31

Last Updated

2025-11-05

Healthy Volunteers

No

Interventions

DRUG

ZYN002 - Cannabidiol Transdermal Gel

Pharmaceutically manufactured. Cannabidiol formulated as a clear gel (transdermal delivery)

Locations (26)

Southwest Autism Research and Resource Center

Phoenix, Arizona, United States

Science 37

Culver City, California, United States

Amnova Clinical Research, LLC

Irvine, California, United States

UC Davis Health System, MIND Institute

Sacramento, California, United States

Children's Hospital of Colorado

Denver, Colorado, United States

Children's Research Institute

Washington D.C., District of Columbia, United States

University of Miami

Miami, Florida, United States

Han Phan

Atlanta, Georgia, United States

Rush University Medical Center

Chicago, Illinois, United States

Kennedy Krieger Institute

Baltimore, Maryland, United States

Boston Children's Hospital

Boston, Massachusetts, United States

Masonic Institute of Developing Brain

Minneapolis, Minnesota, United States

University of Mississipi Medical Center

Jackson, Mississippi, United States

The Fragile X Spectrum Disorder Clinic at Icahn School of Medicine at Mount Sinai, Division of Medical Genetics

New York, New York, United States

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States

Central States Research

Tulsa, Oklahoma, United States

Penn State Milton S. Hershey Medical Center

Hershey, Pennsylvania, United States

Greenwood Genetic Center

Greenville, South Carolina, United States

Primary Children's Hospital

Salt Lake City, Utah, United States

Westmead Children's Hospital

Sydney, New South Wales, Australia

Lady Cilento Children's Hospital - South Brisbane

Brisbane, Queensland, Australia

Genetics Clinics Australia

Melbourne, Victoria, Australia

Wellington Hospital

Wellington, New Zealand

Research Space

Leicester, Leicestershire, United Kingdom

Children's Clinical Research Facility, Royal Hospital for Children and Young People

Edinburgh, Lothian, United Kingdom

Manchester University NHS Foundation Trust

Manchester, United Kingdom