Clinical Research Directory
Browse clinical research sites, groups, and studies.
Closed-loop tDCS in Patients in Minimally Conscious State
Sponsor: University of Liege
Summary
This research will test a closed-loop system using EEG-arousal measures (spectral entropy) to define the best moment of the day for application of transcranial direct current stimulation (tDCS) in patients in MCS This study aims at answering the following questions: 1. Is tDCS applied during high vigilance states more effective in increasing the level of conscious awareness than low vigilance states in patients in minimally conscious state (MCS)? 2. Is the EEG pattern (connectivity, complexity) different after application of active or sham tDCS at high vigilance or low vigilance states? 3. Is there a difference in the profile of tDCS-responders as compared to non-responders with regards to etiology, clinical diagnosis (MCS+/MCS-), age, gender, time post-injury, functional outcome, structural and functional neuroimaging findings and EEG markers?
Official title: Closed-loop Application of tDCS to Promote Responsiveness of Patients in MCS
Key Details
Gender
All
Age Range
16 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
16
Start Date
2019-08-01
Completion Date
2024-12
Last Updated
2024-04-29
Healthy Volunteers
No
Conditions
Interventions
Anodal transcranial direct current stimulation
Neuromodulation of bilateral prefrontal areas using 2 mA tDCS delivered during 20 minutes via sponge electrodes on the scalp
Locations (1)
University Hospital of Liege
Liège, Belgium