Clinical Research Directory

Inclusion Criteria: 1. Age ≥ 18 years 2. Severe, acute traumatic brain injury 3. Diagnosis of Coma, Vegetative State, or Minimally Conscious State Exclusion Criteria: 1. Penetrating brain injury caused by a metallic missile/object (e.g. bullet) 2. Body metal contraindicating MRI 3. Prisoner or ward of the state 4. Neurological 1. Bilateral dilated unresponsive pupils 2. Intracranial hypertension (Intracranial Pressure \[ICP\] \> 25 mmHg for \> 5 min within past 24 hours with head-of-bed at standard clinical angle of 30-45 degrees) 3. Intracranial bolt 4. Status epilepticus or concern for post-ictal state 5. Cardiovascular 1. Poorly controlled hypertension (SBP \> 200 mmHg of DBP \> 120mmHg for 30 minutes, despite anti-hypertensive therapy, within the past 24 hours) 2. Coronary artery disease 3. ST elevation myocardial infarction 4. Acute coronary syndrome 5. Hemodynamically significant dysrhythmia 6. Congestive heart failure 7. Cardiomyopathy (including Takotsubo cardiomyopathy) 8. Other severe structural cardiac abnormalities 6. Renal a. Renal failure requiring renal replacement therapy (e.g. CVVH or HD) 7. Endocrine a. History of or clinical suspicion for thyrotoxicosis 8. Reproductive a. Pregnancy 9. Ophthalmologic a. History of glaucoma 10. Pharmacologic a. Monoamine oxidase inhibitor therapy within past 14 days 11. Other 1. Any condition or finding that in the judgment of the PI or treating clinical team significantly increases the risk or significantly decreases the likelihood of a response to IV MPH