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Closed Loop DBS Implanted RC+S Study
Sponsor: Dennis Turner, M.D.
Summary
This study involves patients who are already planning to have deep brain stimulation (DBS) surgery to treat the symptoms of severe Parkinson's Disease (PD). The study has two goals: 1. to evaluate the effectiveness of implanting DBS electrodes in the two most common locations for DBS (subthalamic nucleus (STN), and globus pallidus interna (GPi)), instead of just one electrode, on each side of the brain; and 2. to develop an adaptive DBS system using brain signals measured from these two electrodes.
Official title: An Integrated Biomarker Approach to Personalized, Adaptive Deep Brain Stimulation in Parkinson Disease [Formerly: Scalar Closed-Loop STN/GPi DBS Based on Evoked and Spontaneous Potentials (Permanently Implanted Medtronic RC+S Studies)]
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
46
Start Date
2019-07-10
Completion Date
2027-01
Last Updated
2026-02-18
Healthy Volunteers
No
Conditions
Interventions
STN alone
DBS stimulation of STN alone
GPi alone
DBS stimulation of GPi alone
STN + GPi
cooperative DBS stimulation of STN and GPi sites
Closed-loop stimulation
adaptive DBS stimulation of STN and/or GPi sites
Locations (1)
Duke University Medical Center
Durham, North Carolina, United States