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Cisplatin Disposition and Kidney Injury
Sponsor: University of Colorado, Denver
Summary
This study is being done to determine 1) whether drugs to treat cisplatin-related nausea can influence harm to the kidneys, 2) whether cisplatin levels in the body can influence the risk of harm to the kidneys, and 3) whether a person's genetic make-up can increase or decrease the likelihood of kidney injury due to cisplatin therapy.
Official title: Drug Disposition and Nephrotoxicity
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
72
Start Date
2019-11-15
Completion Date
2027-12-31
Last Updated
2025-08-11
Healthy Volunteers
No
Conditions
Interventions
Granisetron
An antiemetic regimen containing granisetron 2 mg oral or IV.
Ondansetron
An antiemetic regimen containing ondansetron 8 mg oral or IV.
Palonosetron
An antiemetic regimen containing palonosetron 0.25 mg IV.
Locations (2)
UCHealth-Metro Denver
Denver, Colorado, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States