Clinical Research Directory
Browse clinical research sites, groups, and studies.
Neo-RT: A Study Investigating Whether Changing the Sequence of Treatments (Starting Radiotherapy Followed by Hormone Therapy Before Surgery) is Feasible
Sponsor: CCTU- Cancer Theme
Summary
Four in 10 women diagnosed with breast cancer undergo mastectomy with or without breast reconstruction and less than half are satisfied with how they look unclothed. Breast conservation (removing the area with the lump only) can offer less extensive surgery and improved breast appearance, which can therefore increase well-being. Intensity-modulated radiotherapy (IMRT) closely shapes the radiation beam to the cancer and is currently given after breast surgery. A new combination of IMRT followed by hormone treatment given before surgery, may increase the possibility of breast conservation.
Official title: Neo-RT: Pre-operative Breast Intensity Modulated Radiotherapy in Patients Receiving Neo-adjuvant Hormonal Treatment for Breast Cancer - a Feasibility Study.
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
43
Start Date
2018-03-26
Completion Date
2026-10-15
Last Updated
2026-10-05
Healthy Volunteers
No
Conditions
Interventions
Intensity modulated radiotherapy (IMRT)
Simultaneous integrated boost technique using IMRT: 48 Gray (Gy) and 40 Gy will treat tumour and breast tissue respectively, in 15 fractions over 3 weeks.
Endocrine therapy
Endocrine therapy will commence following completion of radiotherapy, and will continue for 20 weeks.
Breast conserving surgery
Surgery carried out using local protocol following completion of endocrine therapy.
Locations (1)
Cambridge University Hospitals NHS Foundation Trust
Cambridge, Cambridgeshire, United Kingdom