Clinical Research Directory

Inclusion criteria (recipients): 1. Patients with end-stage liver disease listed for liver transplantation at UPMC. 2. Age ≥ 18 3. No available living liver donor 4. Listed for an isolated liver transplant at UPMC 5. Have panel reactive antibody level of \<98% 6. Able to travel to UPMC for routine post-transplant visits and study visits for a minimum of 12 months after transplantation 7. Able to provide informed consent 8. Be willing to use a contraceptive method for a year after transplant Exclusion criteria (recipients): 1. HIV positive 2. HCVAb or HCV RNA positive 3. Presence of behavioral risk factors for contracting HCV. These behavioral risk factors are current injection drug use, current intranasal illicit drug use, current percutaneous/parenteral exposures in an unregulated setting. 4. Hepatitis B surface antigen positive 5. History of atrial fibrillation requiring the use of amiodarone over the past 12m 6. Receipt of prior organ transplant 7. Waitlisted for a multi-organ transplant 8. Pregnant women 9. Known allergy to sofosbuvir/velpatasvir 10. Any condition, psychiatric or physical, that in the opinion of the investigator would make it unsafe to proceed with transplantation or interfere with the ability of the subject to participate in the study Inclusion criteria (donors): 1. HCV antibody positive 2. HCV NAT negative or positive Exclusion criteria (donors): 1. Confirmed HIV positive (positive HIV-1 antibody, positive HIV-2 antibody, positive p24 antigen and/or positive HIV NAT) 2. Confirmed HBV positive (positive hepatitis B surface antigen and/or HBV NAT) 3. Known ongoing therapy for HCV