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Identification of Predictive Blood Biomarkers of Recurrent Urinary Tract Infections
Sponsor: Centre Hospitalier Universitaire de Nice
Summary
Urinary tract infections affect more than 130 million people worldwide each year. Almost 50% of women will have at least one urinary tract infection during their lifetime, usually cystitis. Half of them will have recurrent cystitis. Antibiotics are the first-line treatment for cystitis, but their effectiveness is decreasing due to the rapid spread of multi-resistant uro-pathogenic bacteria. The objective of this study is to identify blood biomarkers associated with a high risk of recurrent cystitis. Immune system cells, and more specifically innate immunity cells, play a key role in controlling urinary tract infections. In addition, clinical studies have shown that there is a high inter-individual variability in the ability of innate immune cells to respond to different stimuli. We therefore hypothesized that there was an association between the risk of recurrent cystitis and a deficiency of certain immune cell types in producing certain pro-inflammatory cytokines, including TNF-α, in response to one or more bacterial stimuli, particularly flagellin.
Key Details
Gender
FEMALE
Age Range
18 Years - 28 Years
Study Type
INTERVENTIONAL
Enrollment
109
Start Date
2019-06-03
Completion Date
2025-12-31
Last Updated
2025-12-03
Healthy Volunteers
Yes
Conditions
Interventions
Collection of blood samples
23 mL of blood will be collected during the inclusion visit
Collection of fecal samples
Fecal sample self-collected after the inclusion visit
Collection of urine samples
10 mL of urine will be collected during the inclusion visit
Collection of vaginal swaps
Sample of vaginal microbiota collected during the inclusion visit
Locations (1)
Hôpital de l'Archet 1 - CHU de Nice - Service d'Infectiologie
Nice, France