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ACTIVE NOT RECRUITING
NCT03819712
NA

Identification of Predictive Blood Biomarkers of Recurrent Urinary Tract Infections

Sponsor: Centre Hospitalier Universitaire de Nice

View on ClinicalTrials.gov

Summary

Urinary tract infections affect more than 130 million people worldwide each year. Almost 50% of women will have at least one urinary tract infection during their lifetime, usually cystitis. Half of them will have recurrent cystitis. Antibiotics are the first-line treatment for cystitis, but their effectiveness is decreasing due to the rapid spread of multi-resistant uro-pathogenic bacteria. The objective of this study is to identify blood biomarkers associated with a high risk of recurrent cystitis. Immune system cells, and more specifically innate immunity cells, play a key role in controlling urinary tract infections. In addition, clinical studies have shown that there is a high inter-individual variability in the ability of innate immune cells to respond to different stimuli. We therefore hypothesized that there was an association between the risk of recurrent cystitis and a deficiency of certain immune cell types in producing certain pro-inflammatory cytokines, including TNF-α, in response to one or more bacterial stimuli, particularly flagellin.

Key Details

Gender

FEMALE

Age Range

18 Years - 28 Years

Study Type

INTERVENTIONAL

Enrollment

109

Start Date

2019-06-03

Completion Date

2025-12-31

Last Updated

2025-12-03

Healthy Volunteers

Yes

Interventions

PROCEDURE

Collection of blood samples

23 mL of blood will be collected during the inclusion visit

OTHER

Collection of fecal samples

Fecal sample self-collected after the inclusion visit

OTHER

Collection of urine samples

10 mL of urine will be collected during the inclusion visit

OTHER

Collection of vaginal swaps

Sample of vaginal microbiota collected during the inclusion visit

Locations (1)

Hôpital de l'Archet 1 - CHU de Nice - Service d'Infectiologie

Nice, France