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Whole Body MRI to Identify Atypical Neurofibromas in Patients With NF1
Sponsor: Children's National Research Institute
Summary
This study is being conducted to determine if Whole Body MRI (WBMRI) can be used to identify Atypical Neurofibromas (ANF) in Neurofibromatosis Type 1 (NF1) patients with high tumor burden. Each enrolled participant will have two (2) WBMRIs without sedation during the study period. Eligible participants must be Male or Female between the ages of 8-30 with diagnosed NF1; with one or more PN greater than 3cm in diameter and willing to comply with study procedures.
Official title: Whole Body MRI to Identify Atypical Neurofibromas in Patients With NF1 and High Plexiform Neurofibroma Tumor Burden
Key Details
Gender
All
Age Range
8 Years - 30 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2018-07-12
Completion Date
2022-08-01
Last Updated
2021-03-02
Healthy Volunteers
No
Conditions
Interventions
Whole Body MRI
WBMRI with axial and coronal STIR (short inversion time inversion recovery) images + DWI (diffuse weighted imaging) will be performed and compared to regional MRI to assess value of this diagnostic test for the identification of suspicious looking lesions (i.e. diffuse nodular lesions or atypical plexiform neurofibroma)
Locations (1)
Children's National Health System
Washington D.C., District of Columbia, United States