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Moderately Hypofractionated Radiotherapy for Prostate Cancer.
Sponsor: Tatarstan Cancer Center
Summary
Radiation therapy is one of the standard treatments for men with prostate cancer. Moderately hypofractionated radiotherapy has been established to be equivalent to standard fractionated radiotherapy in several large randomized clinical trials, however different hypofractionated regimens have been used in these studies. The two most common hypofractionated regimens are 70 Gy in 28 fractions and 60 Gy in 20 fractions, both are considered standard of care, however it is not unknown which regimen is better in terms of effectiveness and toxicity. The aim of this randomized controlled clinical trial is to compare the two hypofractionated radiotherapy regimens using Helical Tomotherapy.
Official title: A Prospective Randomized Phase II Clinical Trial of Moderately Hypofractionated Radiotherapy (70 Gy in 28 Fractions vs 60 Gy in 20 Fractions) Using Helical Tomotherapy.
Key Details
Gender
MALE
Age Range
18 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
400
Start Date
2019-01-25
Completion Date
2030-02-01
Last Updated
2026-04-08
Healthy Volunteers
No
Conditions
Interventions
Hypofractionated IMRT using helical Tomotherapy.
70 Gy in 28 fractions intensity-modulated radiotherapy (IMRT)
Hypofractionated IMRT using helical Tomotherapy.
60 Gy in 20 fractions intensity-modulated radiotherapy (IMRT) using helical Tomotherapy.
Locations (1)
Tatarstan Cancer Cente
Kazan', Tatarstan Republic, Russia