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PErsonalized Genomics for Prenatal Abnormalities Screening USing Maternal Blood
Sponsor: CHU de Quebec-Universite Laval
Summary
This project aims to provide high- quality evidence to inform decisions by health care organisations about using first-tier non-invasive prenatal screening (NIPS) to replace traditional screening tests for trisomy 21, and potentially to screen for other fetal chromosome anomalies. We will compare the current screening approach of second-tier NIPS with the use of first-tier NIPS in a large cohort of pregnant women.
Official title: PErsonalized Genomics for Prenatal Abnormalities Screening USing Maternal Blood : Towards First Tier Screening and Beyond
Key Details
Gender
FEMALE
Age Range
19 Years - Any
Study Type
INTERVENTIONAL
Enrollment
7849
Start Date
2020-01-13
Completion Date
2025-06-30
Last Updated
2025-02-12
Healthy Volunteers
Yes
Conditions
Interventions
Traditional integrated prenatal screening
biochemical prenatal screening with or without nuchal translucency by US
Second-tier Non-invasive prenatal screening (NIPS)
genomics based NIPS after a positive traditional prenatal screen
First-tier Non-invasive prenatal screening (NIPS)
genomics based NIPS at first trimester
Invasive prenatal testing for fetal aneuploidy
amniocentesis or chorionic villi sampling (CVS)
Locations (6)
Kelowna Regional Fertility Center
Kelowna, British Columbia, Canada
Prince Rupert Regional Hospital
Prince Rupert, British Columbia, Canada
Children's & Women's Health Centre
Vancouver, British Columbia, Canada
CHU Ste-Justine
Montreal, Quebec, Canada
CHU de Québec - Université Laval
Québec, Quebec, Canada
CIUSSS Côte-Nord
Sept-Îles, Quebec, Canada