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ACTIVE NOT RECRUITING
NCT03834493
PHASE3

Study of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-641/KEYNOTE-641)

Sponsor: Merck Sharp & Dohme LLC

View on ClinicalTrials.gov

Summary

The purpose of this study is to assess the efficacy and safety of the combination of pembrolizumab (MK-3475) and enzalutamide in the treatment of men with metastatic castration-resistant prostate cancer (mCRPC) who have not received chemotherapy for mCRPC, are abiraterone-naïve, or are intolerant to or progressed on abiraterone acetate. There are two primary study hypotheses. Hypothesis 1: The combination of pembrolizumab plus enzalutamide is superior to placebo plus enzalutamide with respect to Overall Survival (OS). Hypothesis 2: The combination of pembrolizumab plus enzalutamide is superior to placebo plus enzalutamide with respect to Radiographic Progression-free Survival (rPFS) per Prostate Cancer Working Group (PCWG)-modified Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as assessed by blinded independent central review.

Official title: A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (KEYNOTE-641)

Key Details

Gender

MALE

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

1244

Start Date

2019-07-28

Completion Date

2026-05-29

Last Updated

2025-07-18

Healthy Volunteers

No

Interventions

BIOLOGICAL

Pembrolizumab

IV infusion

DRUG

Enzalutamide

Capsules/Tablets

DRUG

Placebo

IV infusion

Locations (259)

University of South Alabama, Mitchell Cancer Institute ( Site 0065)

Mobile, Alabama, United States

Providence Medical Foundation-Oncology ( Site 0069)

Fullerton, California, United States

UCLA Hematology/Oncology - Santa Monica ( Site 0081)

Los Angeles, California, United States

University of Colorado Cancer Center ( Site 0022)

Aurora, Colorado, United States

Smilow Cancer Hospital at Yale New Haven ( Site 0038)

New Haven, Connecticut, United States

Moffitt Cancer Center ( Site 0080)

Tampa, Florida, United States

Georgia Cancer Center at Augusta University ( Site 0026)

Augusta, Georgia, United States

Mount Sinai Hospital ( Site 0042)

Chicago, Illinois, United States

Methodist Hospitals. ( Site 0008)

Merrillville, Indiana, United States

Tulane Cancer Center ( Site 0066)

New Orleans, Louisiana, United States

University of Massachusetts Worcester ( Site 0053)

Worcester, Massachusetts, United States

Cancer & Hematology Centers of Western Michigan ( Site 0013)

Grand Rapids, Michigan, United States

Munson Medical Center ( Site 0030)

Traverse City, Michigan, United States

St. Vincent Frontier Cancer Center ( Site 0016)

Billings, Montana, United States

Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0034)

Omaha, Nebraska, United States

Comprehensive Cancer Centers of Nevada ( Site 0092)

Las Vegas, Nevada, United States

John Theurer Cancer Center at Hackensack University Medical Center ( Site 0004)

Hackensack, New Jersey, United States

Associated Medical Professionals of NY ( Site 0060)

Syracuse, New York, United States

W. G. Bill Hefner VA Medical Center ( Site 0029)

Salisbury, North Carolina, United States

Gabrail Cancer Center-Research ( Site 0096)

Canton, Ohio, United States

Tri-State Urologic Services PSC, Inc. ( Site 0094)

Cincinnati, Ohio, United States

University Hospitals Cleveland Medical Center ( Site 0036)

Cleveland, Ohio, United States

Oregon Health Science University ( Site 0031)

Portland, Oregon, United States

Carolina Urologic Research Center ( Site 0070)

Myrtle Beach, South Carolina, United States

Inova Schar Cancer Institute ( Site 0006)

Fairfax, Virginia, United States

Virginia Cancer Institute ( Site 0052)

Richmond, Virginia, United States

Blue Ridge Cancer Care ( Site 0086)

Roanoke, Virginia, United States

Froedtert Hospital & the Medical College of Wisconsin ( Site 0045)

Milwaukee, Wisconsin, United States

Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 1013)

Berazategui, Buenos Aires, Argentina

Organizacion Medica de Investigacion ( Site 1019)

CABA, Buenos Aires, Argentina

Instituto Medico Alexander Fleming ( Site 1010)

Ciudad Autonoma de Buenos Aires., Buenos Aires, Argentina

Instituto de Investigaciones Clinicas ( Site 1000)

Mar del Plata, Buenos Aires, Argentina

Centro de Diagnostico Urologico ( Site 1008)

Buenos Aires, Buenos Aires F.D., Argentina

Sanatorio Parque ( Site 1002)

Rosario, Santa Fe Province, Argentina

Instituto de Oncologia de Rosario ( Site 1015)

Rosario, Santa Fe Province, Argentina

Instituto de Investigaciones Metabolicas [Buenos Aires, Argentina] ( Site 1011)

Buenos Aires, Argentina

Hospital Aleman ( Site 1004)

Buenos Aires, Argentina

Centro Medico Dra De Salvo ( Site 1018)

Buenos Aires, Argentina

CEMAIC ( Site 1014)

Córdoba, Argentina

Centro Oncologico Riojano Integral ( Site 1005)

La Rioja, Argentina

Centro Oncologico de Integracion Regional. COIR ( Site 1007)

Mendoza, Argentina

St. Vincent's Hospital ( Site 0158)

Darlinghurst, New South Wales, Australia

St George Hospital ( Site 0157)

Kogarah, New South Wales, Australia

Macquarie University ( Site 0151)

Macquarie University, New South Wales, Australia

Port Macquarie Base Hospital ( Site 0153)

Port Macquarie, New South Wales, Australia

Calvary Mater Newcastle ( Site 0148)

Waratah, New South Wales, Australia

Gallipoli Medical Research Ltd ( Site 0149)

Greenslopes, Queensland, Australia

Gold Coast University Hospital ( Site 0150)

Southport, Queensland, Australia

Royal Adelaide Hospital ( Site 0154)

Adelaide, South Australia, Australia

Monash Medical Centre ( Site 0147)

Clayton, Victoria, Australia

Fiona Stanley Hospital ( Site 0162)

Perth, Western Australia, Australia

Ordensklinikum Linz GmbH Elisabethinen ( Site 0373)

Linz, Upper Austria, Austria

Medizinische Universität Wien ( Site 0375)

Vienna, Austria

Hospital Erasto Gaertner-CEPEP - Pesquisa Clínica ( Site 1036)

Curitiba, Paraná, Brazil

Liga Norte Riograndense Contra o Câncer-Centro de Pesquisa Clínica ( Site 1032)

Natal, Rio Grande do Norte, Brazil

ONCOSITE - Centro de Pesquisa Clinica em Oncologia ( Site 1038)

Ijuí, Rio Grande do Sul, Brazil

Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 1021)

Porto Alegre, Rio Grande do Sul, Brazil

Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 1035)

Itajaí, Santa Catarina, Brazil

Hospital de Base de Sao Jose de Rio Preto ( Site 1022)

São José do Rio Preto, São Paulo, Brazil

A.C. Camargo Cancer Center ( Site 1026)

São Paulo, Brazil

Núcleo de Pesquisa Clínica da Rede São Camilo ( Site 1040)

São Paulo, Brazil

MHAT Serdika-Second Department of Medical Oncology ( Site 0505)

Sofia, Sofia (stolitsa), Bulgaria

MHAT Central Hospital ( Site 0503)

Plovdiv, Bulgaria

Complex Cancer Center Plovdiv-First Medical Oncology Department ( Site 0507)

Plovdiv, Bulgaria

BC Cancer Victoria-Clinical Trials Unit ( Site 0111)

Victoria, British Columbia, Canada

Health Sciences North ( Site 0122)

Greater Sudbury, Ontario, Canada

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0116)

Hamilton, Ontario, Canada

Grand River Hospital ( Site 0120)

Kitchener, Ontario, Canada

Lakeridge Health ( Site 0117)

Oshawa, Ontario, Canada

Sunnybrook Research Institute ( Site 0108)

Toronto, Ontario, Canada

Princess Margaret Cancer Centre ( Site 0107)

Toronto, Ontario, Canada

CISSS de la Monteregie-Centre ( Site 0119)

Greenfield Park, Quebec, Canada

Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0106)

Montreal, Quebec, Canada

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0103)

Québec, Quebec, Canada

CIUSSS du Bas Saint Laurent - Hopital Regional de Rimouski ( Site 0102)

Rimouski, Quebec, Canada

CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0105)

Sherbrooke, Quebec, Canada

Fundacion Arturo Lopez Perez ( Site 1049)

Santiago, Region M. de Santiago, Chile

Pontificia Universidad Catolica de Chile ( Site 1047)

Santiago, Region M. de Santiago, Chile

Bradfordhill ( Site 1044)

Santiago, Region M. de Santiago, Chile

Centro Investigación del Cáncer James Lind ( Site 1041)

Temuco, Región de la Araucanía, Chile

Rey y Oreilly Limitada ( Site 1048)

Temuco, Región de la Araucanía, Chile

Oncocentro ( Site 1045)

Viña del Mar, Región de Valparaíso, Chile

Hospital Pablo Tobon Uribe ( Site 1066)

Medellín, Antioquia, Colombia

Biomelab S A S ( Site 1067)

Barranquilla, Atlántico, Colombia

Clinica de la Costa S.A.S. ( Site 1073)

Barranquilla, Atlántico, Colombia

Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 1062)

Bogotá, Bogota D.C., Colombia

Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 1068)

Valledupar, Cesar Department, Colombia

Oncomédica S.A.S ( Site 1057)

Montería, Departamento de Córdoba, Colombia

Clínica Imbanaco S.A.S ( Site 1064)

Cali, Valle del Cauca Department, Colombia

Hemato Oncologos S.A. ( Site 1065)

Cali, Valle del Cauca Department, Colombia

Fakultni Nemocnice u sv. Anny v Brne-Onkologicko-chirurgicke oddeleni ( Site 1303)

Brno, Brno-mesto, Czechia

Nemocnice AGEL Novy Jicin a.s. ( Site 1304)

Nový Jičín, Novy Jicin, Czechia

Fakultni nemocnice Olomouc ( Site 1301)

Olomouc, Olomoucký kraj, Czechia

C.H. de Saint Quentin ( Site 0481)

Saint-Quentin, Aisne, France

Centre Jean Perrin ( Site 0434)

Clermont-Ferrand, Auvergne, France

Clinique Sainte Anne ( Site 0431)

Strasbourg, Bas-Rhin, France

CHU de Brest -Site Hopital Morvan ( Site 0441)

Brest, Brittany Region, France

CHU Jean Minjoz ( Site 0423)

Besançon, Doubs, France

Institut Bergonie ( Site 0421)

Bordeaux, Gironde, France

Institut Claudius Regaud IUCT Oncopole ( Site 0418)

Toulouse, Haute-Garonne, France

Hopital Foch ( Site 0428)

Suresnes, Hauts-de-Seine, France

Institut Regional du Cancer de Montpellier - ICM ( Site 0443)

Montpellier, Herault, France

Institut De Cancerologie De L Ouest ( Site 0448)

Saint-Herblain, Loire-Atlantique, France

Centre Hospitalier Regional du Orleans ( Site 0430)

Orléans, Loiret, France

Centre D Oncologie de Gentilly ( Site 0432)

Nancy, Meurthe-et-Moselle, France

Centre Hospitalier de Valenciennes ( Site 0439)

Valenciennes, Nord, France

C.H.U. Lyon Sud ( Site 0436)

Pierre-Bénite, Rhone, France

CHU Amiens Picardie Site Sud Amiens ( Site 0438)

Amiens, Somme, France

Institut Gustave Roussy ( Site 0416)

Villejuif, Val-de-Marne, France

Institut Sainte Catherine ( Site 0447)

Avignon, Vaucluse, France

Institut Mutualiste Montsouris ( Site 0446)

Paris, France

Universitaetsklinikum Freiburg - Medizinische Klinik ( Site 0304)

Freiburg im Breisgau, Baden-Wurttemberg, Germany

Studienpraxis Urologie ( Site 0309)

Nürtingen, Baden-Wurttemberg, Germany

Universitaetsklinik fuer Urologie ( Site 0307)

Tübingen, Baden-Wurttemberg, Germany

Klinikum Rechts der Isar ( Site 0300)

Munich, Bavaria, Germany

Universitaetsklinik der Paracelsus Medizinischen Privatuniversitaet ( Site 0318)

Nuremberg, Bavaria, Germany

Universitaetsklinikum Goettingen ( Site 0345)

Göttingen, Lower Saxony, Germany

Uniklinik RWTH Aachen ( Site 0308)

Aachen, North Rhine-Westphalia, Germany

Universitaetsklinikum Muenster ( Site 0320)

Münster, North Rhine-Westphalia, Germany

Krankenhaus der Barmherzigen Brueder Trier ( Site 0310)

Trier, Rhineland-Palatinate, Germany

Universitaetsklinikum des Saarlandes ( Site 0348)

Homburg, Saarland, Germany

Universitaetsklinikum Schleswig Holstein. ( Site 0346)

Lübeck, Schleswig-Holstein, Germany

Universitaetsklinikum Jena ( Site 0305)

Jena, Thuringia, Germany

Charite Universitaetsmedizin Berlin ( Site 0301)

Berlin, Germany

Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 1321)

Kecskemét, Bács-Kiskun county, Hungary

Petz Aladár Megyei Oktató Kórház-Onkológiai Osztály ( Site 1324)

Győr, Győr-Moson-Sopron, Hungary

Országos Onkológiai Intézet-Urogenital Tumors Department and Clinical Pharmacology ( Site 1325)

Budapest, Pest County, Hungary

Magyar Honvedseg Egeszsegugyi Kozpont-Onkologiai Osztaly ( Site 1326)

Budapest, Hungary

Beaumont Hospital ( Site 0726)

Dublin, Ireland

Tallaght University Hospital ( Site 0730)

Dublin, Ireland

Mid Western Cancer Centre ( Site 0728)

Limerick, Ireland

HaEmek Medical Center ( Site 0548)

Afula, Israel

Assuta Ashdod Medical Center ( Site 0550)

Ashdod, Israel

Soroka Medical Center ( Site 0549)

Beersheba, Israel

Rambam Health Care Campus-Oncology Division ( Site 0543)

Haifa, Israel

Hadassah Ein Kerem Medical Center ( Site 0546)

Jerusalem, Israel

Meir Medical Center ( Site 0544)

Kfar Saba, Israel

Rabin Medical Center ( Site 0545)

Petah Tikva, Israel

Chaim Sheba Medical Center ( Site 0541)

Ramat Gan, Israel

Sourasky Medical Center ( Site 0542)

Tel Aviv, Israel

Yitzhak Shamir Medical Center. ( Site 0547)

Ẕerifin, Israel

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori-Oncologia Medica ( Site 0464)

Meldola, Emilia-Romagna, Italy

A.O. Universitaria di Modena ( Site 0454)

Modena, Emilia-Romagna, Italy

Istituto Clinico Humanitas Research Hospital ( Site 0452)

Rozzano, Lombardy, Italy

Presidio Ospedaliero S. Maria Delle Grazie-U.O.C. ONCOLOGIA ( Site 0802)

Pozzuoli, Napoli, Italy

Centro Di Riferimento Oncologico ( Site 0800)

Aviano, Pordenone, Italy

Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Roma-Oncology Unit ( Site 0465)

Verona, Veneto, Italy

Medical Oncology Ospedale San Donato ( Site 0461)

Arezzo, Italy

Ospedale Policlinico S. Orsola-Malpighi ( Site 0453)

Bologna, Italy

Azienda Ospedaliera Cannizzaro ( Site 0458)

Catania, Italy

Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 0462)

Naples, Italy

Azienda Ospedaliera San Camillo Forlanini ( Site 0455)

Roma, Italy

Fondazione Policlinico Universitario Agostino Gemelli ( Site 0801)

Roma, Italy

Azienda Ospedaliera Santa Maria Terni ( Site 0456)

Terni, Italy

Az. Osp. Univ. Sta Maria della Misericordia di Udine ( Site 0460)

Udine, Italy

National Cancer Center Hospital East ( Site 0702)

Kashiwa, Chiba, Japan

Toho University Sakura Medical Center ( Site 0703)

Sakura, Chiba, Japan

National Hospital Organization Shikoku Cancer Center ( Site 0716)

Matsuyama, Ehime, Japan

Iizuka Hospital ( Site 0744)

Iizuka, Fukuoka, Japan

Hakodate Goryoukaku Hospital ( Site 0739)

Hakodate, Hokkaido, Japan

Kanazawa University Hospital ( Site 0701)

Kanazawa, Ishikawa-ken, Japan

Kitasato University Hospital ( Site 0705)

Sagamihara, Kanagawa, Japan

Yokohama City University Medical Center ( Site 0706)

Yokohama, Kanagawa, Japan

Miyagi Cancer Center ( Site 0747)

Natori-shi, Miyagi, Japan

Nara Medical University Hospital ( Site 0715)

Kashihara, Nara, Japan

Kindai University Hospital ( Site 0714)

Sayama, Osaka, Japan

The University of Osaka Hospital ( Site 0713)

Suita, Osaka, Japan

Saitama Medical University International Medical Center ( Site 0708)

Hidaka, Saitama, Japan

Saitama Medical Center ( Site 0743)

Kawagoe, Saitama, Japan

Dokkyo Medical University Saitama Medical Center ( Site 0707)

Koshigaya, Saitama, Japan

Hamamatsu University Hospital ( Site 0720)

Hamamatsu, Shizuoka, Japan

Yamaguchi University Hospital ( Site 0717)

Ube, Yamaguchi, Japan

Chiba Cancer Center ( Site 0704)

Chiba, Japan

Kyushu University Hospital ( Site 0718)

Fukuoka, Japan

Hiroshima Prefectural Hospital ( Site 0748)

Hiroshima, Japan

University of Miyazaki Hospital ( Site 0721)

Miyazaki, Japan

Nagasaki University Hospital ( Site 0719)

Nagasaki, Japan

Toranomon Hospital ( Site 0711)

Tokyo, Japan

Nippon Medical School Hospital ( Site 0709)

Tokyo, Japan

Keio University Hospital ( Site 0710)

Tokyo, Japan

Radboud University Medical Center ( Site 0470)

Nijmegen, Gelderland, Netherlands

Maastricht University Medical Centre ( Site 0467)

Maastricht, Limburg, Netherlands

Amphia Hospital Location Molengracht ( Site 0474)

Breda, North Brabant, Netherlands

Catharina Ziekenhuis ( Site 0472)

Eindhoven, North Brabant, Netherlands

Noordwest Ziekenhuisgroep NWZ ( Site 0468)

Alkmaar, North Holland, Netherlands

Vrije Universiteit Medisch Centrum ( Site 0479)

Amsterdam, North Holland, Netherlands

Tergooiziekenhuizen ( Site 0466)

Hilversum, North Holland, Netherlands

Spaarne Ziekenhuis ( Site 0473)

Hoofddorp, North Holland, Netherlands

Ziekenhuisgroep Twente ( Site 0469)

Hengelo, Overijssel, Netherlands

Haaglanden MC - locatie Antoniushove ( Site 0471)

Leidschendam, South Holland, Netherlands

Franciscus Gasthuis en Vlietland ( Site 0489)

Schiedam, South Holland, Netherlands

Tauranga Hospital ( Site 0215)

Tauranga, Bay of Plenty, New Zealand

Canterbury Regional Cancer & Blood Service ( Site 0195)

Christchurch, Canterbury, New Zealand

Auckland City Hospital ( Site 0193)

Auckland, New Zealand

Przychodnia Lekarska Komed ( Site 0628)

Konin, Greater Poland Voivodeship, Poland

Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 0636)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland

Clinical Best Solutions ( Site 0622)

Warsaw, Masovian Voivodeship, Poland

Szpital Wojewodzki im. Mikolaja Kopernika ( Site 0624)

Koszalin, West Pomeranian Voivodeship, Poland

Salve Medica SP ( Site 0686)

Lodz, Łódź Voivodeship, Poland

Provita Prolife Centrum Medyczne ( Site 0630)

Tomaszów Mazowiecki, Łódź Voivodeship, Poland

Puerto Rico Medical Research Center LLC ( Site 1122)

San Juan, Puerto Rico

FDI Clinical Research ( Site 1121)

San Juan, Puerto Rico

Chelyabinsk Regional Clinical Oncological Dispensary ( Site 0565)

Chelyabinsk, Chelyabinsk Oblast, Russia

Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0585)

Krasnoyarsk, Krasnoyarsk Krai, Russia

State Budgetary Healthcare Institution "Leningrad Regional Clinical Hospital" ( Site 0588)

Gatchina, Leningradskaya Oblast', Russia

Russian Scientific Center of Roentgenoradiology ( Site 0559)

Moscow, Moscow, Russia

Central Clinical Hospital with Polyclinic ( Site 0562)

Moscow, Moscow, Russia

Omsk Clinical Oncology Dispensary ( Site 0568)

Omsk, Omsk Oblast, Russia

SBHI Samara Regional Clinical Oncology Dispensary ( Site 0576)

Samara, Samara Oblast, Russia

Clinical Research Center of specialized types medical care-Oncology ( Site 0570)

Saint Petersburg, Sankt-Peterburg, Russia

Russian Scientific Center of Radiology and Surgical Technologies ( Site 0567)

Saint Petersburg, Sankt-Peterburg, Russia

Tomsk National Scientific Medical Center of Russian Academy of Science ( Site 0579)

Tomsk, Tomsk Oblast, Russia

National Cancer Center ( Site 0174)

Goyang-si, Kyonggi-do, South Korea

Seoul National University Bundang Hospital ( Site 0175)

Seongnam-si, Kyonggi-do, South Korea

Asan Medical Center ( Site 0176)

Songpagu, Seoul, South Korea

Seoul National University Hospital ( Site 0171)

Seoul, South Korea

Samsung Medical Center ( Site 0172)

Seoul, South Korea

Instituto Catalan de Oncologia - ICO ( Site 0330)

L'Hospitalet de Llobregat, Barcelona, Spain

Hospital Parc Tauli ( Site 0335)

Sabadell, Barcelona, Spain

Institut Català d'Oncologia (ICO) - Girona ( Site 0321)

Girona, Gerona, Spain

Instituto Valenciano de Oncologia ( Site 0331)

Valencia, Valenciana, Comunitat, Spain

Hospital del Mar ( Site 0333)

Barcelona, Spain

Hospital Provincial San Pedro Alcantara ( Site 0326)

Cáceres, Spain

Hospital Universitario Gregorio Maranon ( Site 0327)

Madrid, Spain

MD Anderson Cancer Center Madrid ( Site 0332)

Madrid, Spain

Hospital Clinico San Carlos ( Site 0324)

Madrid, Spain

Hospital Universitario HM Sanchinarro ( Site 0322)

Madrid, Spain

Hospital Quiron Madrid ( Site 0325)

Madrid, Spain

Hospital Universitario Virgen de la Victoria ( Site 0337)

Málaga, Spain

Hospital Virgen del Rocio ( Site 0329)

Seville, Spain

National Cheng Kung University Hospital ( Site 0134)

Tainen, Tainan, Taiwan

China Medical University Hospital ( Site 0132)

Taichung, Taiwan

Taichung Veterans General Hospital ( Site 0133)

Taichung, Taiwan

National Taiwan University Hospital ( Site 0131)

Taipei, Taiwan

Taipei Veterans General Hospital ( Site 0135)

Taipei, Taiwan

Ege University Medicine of Faculty ( Site 0661)

Bornova, İzmir, Turkey (Türkiye)

Baskent University Dr. Turgut Noyan Research and Training Center-ONCCOLOGY ( Site 0618)

Adana, Turkey (Türkiye)

Ankara University Hospital Cebeci ( Site 0613)

Ankara, Turkey (Türkiye)

Hacettepe Universitesi-oncology hospital ( Site 0615)

Ankara, Turkey (Türkiye)

Ankara City Hospital-Medical Oncology ( Site 0616)

Ankara, Turkey (Türkiye)

T.C. Saglik Bakanligi Turkiye Kamu Hastaneleri Kurumu - Baki-Istanbul Bakirkoy Sadi Konuk Training ( Site 0620)

Istanbul, Turkey (Türkiye)

Acıbadem Maslak Hastanesi ( Site 0660)

Istanbul, Turkey (Türkiye)

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 0619)

Istanbul, Turkey (Türkiye)

Cherkasy Regional Oncology Dispensary ( Site 1203)

Cherkassy, Cherkasy Oblast, Ukraine

Dnepropetrovsk Regional Clinical Hospital Mechnikov-Department of urology ( Site 1205)

Dnipro, Dnipropetrovsk Oblast, Ukraine

Dnepropetrovsk Regional Clinical Oncology Hospital-Clinical oncological dispensary ( Site 1201)

Dnipropetrovsk, Dnipropetrovsk Oblast, Ukraine

Ivano-Frankivsk Regional Hospital-Urology department ( Site 1208)

Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine

Communal Non-Commercial Enterprise ""Prykarpatski Clinical Oncological Center"" of Ivano-Frankivsk R ( Site 1209)

Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine

CNPE Regional Center of Oncology-oncourology department ( Site 1202)

Kharkiv, Kharkivs’ka Oblast’, Ukraine

LISOD - Israeli Oncological Hospital ""MedX-ray Internationa-Department of Clinical and Scientific ( Site 1207)

Kiev, Kyivska Oblast, Ukraine

Municipal non-profit enterprise Kyiv City Clinical Oncology -Oncourology department ( Site 1204)

Kyiv, Kyivska Oblast, Ukraine

University Hospitals Bristol NHS Foundation Trust ( Site 0530)

Bristol, Bristol, City of, United Kingdom

Cambridge University Hospitals NHS Trust ( Site 0540)

Cambridge, Cambridgeshire, United Kingdom

Torbay Hospital ( Site 0532)

Torquay, Devon, United Kingdom

University College London Hospitals NHS Foundation Trust ( Site 0482)

London, London, City of, United Kingdom

Western General Hospital ( Site 0531)

Edinburgh, Midlothian, United Kingdom

Royal Marsden Hospital (Sutton) ( Site 0526)

London, Surrey, United Kingdom

Musgrove Park Hospital ( Site 0537)

Taunton, Worcestershire, United Kingdom

Mount Vernon Cancer Centre ( Site 0536)

Northwood, United Kingdom