Clinical Research Directory

Inclusion Criteria: * Stage III and IV periodontitis (generalized moderate to severe chronic periodontitis) * At least 4 teeth (to include at least one qualifying tooth on the right and left side of the mouth) with probing depths of 6 to 9 millimeters and bleeding on probing * at least 18 years of age * consent to be in the study * non-emergent dental treatment * American Society of Anesthesiologists (ASA) Class I or II (prticipants that are systemically healthy or have a systemic condition that is well controlled and are able to receive elective dental care) Exclusion Criteria: * \<18 years old or \>100 years old * currently pregnant or within 6 months postpartum, nursing * require antibiotic prophylaxis prior to dental procedures as outlined by the 2017 American Heart Association guidelines * decisionally challenged adults * ASA Class III or IV (patients that have non-controlled systemic conditions that are unable to have elective dental care) * had periodontal therapy within 6 months of baseline treatment visit * antibiotic therapy within 3 months prior to enrollment * chronic therapy within 1 month prior to enrollment with medications that could affect periodontal status or healing