Clinical Research Directory

Inclusion Criteria: * At patient level: * Written informed consent * Age ≥ 18 years * Sufficient complete dentures (Marxkors and Ferger, 1989) not older than 1 year * Patient is unsatisfied with mandibular denture to the degree that he/she seeks treatment * At site level: * Healed edentulous mandible (minimum 8 weeks since last extraction) * Minimal ridge dimensions 5.5 mm (width) by 12 mm (height) in the anterior (interforaminal) area, allowing the placement of 3.3 (endosseous diameter) by 10 mm (length) implants * Opposing dentition: complete denture on a edentulous maxilla * Physical status (PS) 1 and 2 (American Society of Anesthesiologists) Exclusion Criteria: * At patient level * Any physical or mental disorder that would interfere with the ability to perform adequate oral hygiene or the capability of providing written informed consent and compliance to the protocol * Any disorder that would interfere with wound healing or represent a contraindication for oral surgery such as, but not limited to, uncontrolled diabetes or conditions resulting in or requiring immunosuppression, radiation, chemotherapy, frequent use of antibiotics or antiresorptive medication such as bisphosphonates * Pregnancy or lactation * Heavy smoking habit with \> 20 cig/d * Severe bruxism or clenching habits, present oro-facial pain * At site level: * Ridge defects requiring staged bone augmentation procedures (simultaneous Guided Bone Regeneration (GBR) within the ridge contour allowed)