Clinical Research Directory

Inclusion Criteria: 1. Histologic diagnosis of squamous cell carcinoma or adenocarcinoma of thoracic esophageal carcinoma or gastroesophageal junction cancer with Stage T1-4aN0-3M0, according to 8th edition of Union for International Cancer Control (UICC) staging system 2. More than 6 months of expected survival 3. Age ranges from 18 to75 years 4. Absolute white blood cells count ≥4.0×109/L, neutrophil ≥1.5×109/L, platelets ≥100.0×109/L, hemoglobin ≥90g/L, and normal functions of liver and kidney. 5. WHO performance status (PS) of 0-1 6. Informed consent will be obtained before the study Exclusion Criteria: 1. Patients who have undergone definitive chemoradiotherapy 2. Patients with concomitant hemorrhagic disease 3. Patients with other uncontrollable status that cannot tolerate surgery 4. Patients with known hypersensitivity to the porcine fibrin sealant product 5. Pregnant or breast feeding 6. Patients cannot signed the informed consent document because of psychological quality, family and social factors 7. Patients with concomitant peripheral neuropathy, whose CTC status is 2 or even more 8. Have a history of diabetes over 10 years and with poorly controlled blood sugar level 9. Patients with serious cardiac, respiratory, hepatic, renal,hematologic, immunological disease or cachexy, who cannot tolerate surgery