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Impact of Thrombocytopenia and Platelet Transfusions on Neonatal Bleeding and Inflammation
Sponsor: Boston Children's Hospital
Summary
This is a prospective observational study that was designed with the following two Specific Aims: 1. To determine whether the Immature Platelet Fraction percentage (IPF%) and the Immature Platelet Count (IPC) are better predictors of bleeding than the platelet count alone in neonates of different gestational and post-conceptional ages and with different etiologies of thrombocytopenia; and 2. To characterize the effects of neonatal thrombocytopenia and platelet transfusions (PLT Tx) on bleeding and on markers of systemic inflammation, thrombosis, and neutrophil extracellular traps (NET) formation in neonates with different underlying conditions.
Key Details
Gender
All
Age Range
0 Days - 6 Months
Study Type
OBSERVATIONAL
Enrollment
160
Start Date
2019-08-19
Completion Date
2026-09-01
Last Updated
2024-05-16
Healthy Volunteers
No
Conditions
Locations (2)
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Boston Children's Hospital
Boston, Massachusetts, United States