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A Pathophysiological Study of the Postprandial Human Liver (PLS)
Sponsor: Copenhagen University Hospital, Hvidovre
Summary
Fatty liver disease is a globally widespread disease. The identification of valid biomarkers and targets for potential treatments requires in-depth knowledge about the pathophysiology of the postprandial liver. The study will consist of seven work packages (WP) including blood tests and liver biopsies taken after fasting or ingestion of a standardized meal in: healthy controls (WP 1), patients with NAFLD (WP 2), and patients with cirrhosis (WP 3) ; before and after a standardised meal in healthy controls (WP 4), and before and after glucagon in healthy controls (WP5), patients with NAFLD (WP6), and patients with T2DM and NAFLD (WP7).
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
87
Start Date
2019-03-02
Completion Date
2025-09-01
Last Updated
2026-07-06
Healthy Volunteers
Yes
Conditions
Interventions
Standardised meal
Standardised meal (Nutridrink, Nutricia, 300 kcal, 18.4 g carbohydrates, 5.8 g fat, 12 g protein).
Glucagon bolus
Intravenous bolus of 0.2 mg glucagon
Locations (1)
Gastrounit, Copenhagen University Hospital Hvidovre
Hvidovre, Capital Region Denmark, Denmark