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Pharmacological Activation of HMN for OSA Aim 2
Sponsor: Brigham and Women's Hospital
Summary
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon leads to increased collapsibility of UA compared to normal subjects. In this protocol the investigators will test the effect of LTM1201AZ, LTM1201AT, LTM1201AD, LTM1201AG administered before sleep on OSA phenotype traits and OSA severity during sleep.
Official title: Pharmacological Activation of Hypoglossal Motor Nucleus for Obstructive Sleep Apnea Aim 2
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
16
Start Date
2019-03-01
Completion Date
2022-12-31
Last Updated
2022-09-21
Healthy Volunteers
No
Conditions
Interventions
Placebo oral capsule
Placebo capsule before bedtime
LTM1201AZ
LTM1201AZ oral capsule before sleep
LTM1201AT
LTM1201AT oral capsule before sleep
LTM1201AG
LTM1201AG oral capsule before sleep
LTM1201AD
LTM1201AD oral capsule before sleep
Locations (1)
Brigham and Women's Hospital
Boston, Massachusetts, United States