Clinical Research Directory

Acute Intestinal Failure in Critically Ill Patients and Microbial Translocation

Sponsor: Centre Hospitalier Universitaire de Nīmes

Summary

The hypothesis of the investigators is that patients with septic shock in ICU have acute intestinal insufficiency favoring subclinical microbial translocation, which is the consequence of alterations of the epithelium, and is accompanied by qualitative and quantitative changes in the gut microbiota. The primary objective is to determine the incidence of microbial translocation by measuring 16S rDNA and 18S rDNA plasma levels in a patient population with septic shock. Secondary objectives are: * Describe the kinetics of markers of intestinal insufficiency (I-FABP / zonulin) over time (at admission, 12 hours after admission, one day, two day, three days and seven day after admission). * Study the correlation between the titer of I-FABP, zonulin, 16srDNA, 18srDNA and the stages of acute gastrointestinal insufficiency (AGF). * Establish correlations between the microorganisms of the intestinal microbiota and the bacteria involved in microbial translocation. * Study the possible correlations between the 16SrDNA levels and the other bacterial markers (sCD14, LBP). * Describe the evolution of the composition and the diversity of the gut microbiota in the first 7 days of septic shock

Official title: Insuffisance Gastro-intestinale Aiguë Translocation Microbienne Chez Les Patients en Choc Septique : Une étude Pilote

Key Details

Conditions

Locations (1)