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Image-guided Focal Brachytherapy Utilizing Combined 18F-DCFPyl PET/CT
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Summary
The Principal Investigator's (PI) working hypothesis is that the PI can utilize the high predictive value of 18F-DCFPyl PSMA to identify clinically significant tumors in patients who will undergo brachytherapy, as well as areas which are uninvolved or contain only clinically insignificant disease. In the PI's clinical trial, the uninvolved regions (as defined by combined PET-MR-biopsy data) will not be targeted and receive only fall-off dose, which we have shown to be associated with reductions in toxicity.
Official title: Image-guided Focal Brachytherapy Utilizing Combined 18F-DCFPyl PET/CT and Dynamic Dosimetry With Registered Ultrasound and Fluoroscopy for Localized Prostate Cancer
Key Details
Gender
MALE
Age Range
18 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2023-08-03
Completion Date
2033-12
Last Updated
2026-02-13
Healthy Volunteers
No
Conditions
Interventions
Focal brachytherapy with PSMA PET imaging
Focal brachytherapy with PSMA PET imaging. Focal (partial prostate gland) brachytherapy following 18F-DCFPyl PET/CT radiotracer imaging. Patients will also undergo pre-treatment transperineal mapping biopsy.
(18F)DCFPyL
18F-DCFPyl PET/CT scan
Locations (1)
SKCCC at Johns Hopkins
Baltimore, Maryland, United States