Clinical Research Directory

Inclusion Criteria: * Prior or ongoing harmful alcohol intake defined as an average of ≥24g alcohol/day for women and ≥36g/d for men for ≥ 5 year. * Outpatients with compensated advanced chronic alcohol-related liver disease, defined as stable patients with: 1. liver stiffness ≥15 kPa and asymptomatic and/or 2. New liver biopsy (\<6months) with at least F3 fibrosis (kleiner) and/or 3. Liver biopsy older that 6 months with liver stiffness ≥10 kPa * Understand and speak Danish written and orally * Informed consent Exclusion Criteria: * Hospitalised * Moderete or severe Ascites, determined from imaging diagnostics * High-risk varices needing interventional treatment (endoscopy, TIPS) * Child-Pugh C score * MELD-Na ≥15 * Lactose intolerance * Coeliac disease * Irritable bowel syndrome defined by ROME III criteria * Antibiotic treatment the prior 3 months * Treatment with nutritional drinks, probiotics or prebiotics within the last 3 months * The investigator judge that the patient would not be compliant with trial medicine * Pregnancy * Known liver disease other than alcoholic, of any aetiology * Severe malnutrition * Malignancy - except spino- or basocellular skin cancer. Patients with prior malignant disease are allowed if cancer-free for at least one year * Recent infectious gastroenteritis (for the last 6 weeks)