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Cold Snare Endoscopic Mucosal Resection Trial
Sponsor: White River Junction Veterans Affairs Medical Center
Summary
This study compares different approaches to endoscopic mucosal resection (EMR) of large non-pedunculated colorectal polyps (≥20mm) in a 2 x 2 randomized design. The first randomization will assign half of patients to polyp resection with electrocautery ("hot" snare EMR) and half of patient to polyp resection without electrocautery ("cold" snare EMR). The second randomization will assign half of patients to polyp removal using Eleview as the submucosal injection agent, and the other half using placebo (normal saline with methylene blue) as the submucosal injection agent.
Official title: Cold Endoscopic Resection of Large Colorectal Polyps: A Randomized Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
990
Start Date
2019-10-01
Completion Date
2027-01
Last Updated
2024-06-21
Healthy Volunteers
No
Interventions
Cold snare EMR
Participants will have their large polyp removed without electrocautery
Hot snare EMR
Participants will have their large polyp removed with electrocautery
Eleview injection
Participants will have their polyp submucosally injected with Eleview
Placebo injection
Participants will have their polyp submucosally injected with placebo
Locations (1)
White River Junction VAMC
White River Junction, Vermont, United States