Clinical Research Directory

Inclusion Criteria: * Histologically or cytologically confirmed non-small cell lung cancer. * The ECOG score of performance status is 0-1. * Locally advanced or recurrent metastatic NSCLC that has never received systemic treatment. * According to RECIST1.1 criteria, there is at least 1 measurable lesion that has not been previously irradiated. * Prior to enrollment, a central laboratory testing report has confirmed that the tumor has one of two common EGFR mutations positive that are sensitive to EGFR-TKI therapy, accompanied with or not accompanied with other EGFR mutation, with the exception of exon 20 insertion. Exclusion Criteria: * Previously received systemic treatment for locally advanced or recurrent metastatic cancer. * Primary T790M mutation-positive patient. * Previous interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonia requiring hormonal therapy, or any clinically proven active interstitial lung disease. * Known active infections such as hepatitis B, hepatitis C, and human immunodeficiency virus. * Local radiation therapy is carried out within 1 week; more than 30% bone marrow radiation therapy or extensive radiation therapy is performed within 4 weeks. * ≤ 4 weeks from major surgery or ≤ 2 weeks from minor surgery.