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ACTIVE NOT RECRUITING
NCT03878407

Identification of Patients With Age-Related Clonal Hematopoiesis (ARCH) Among Cancer Survivors

Sponsor: University Health Network, Toronto

View on ClinicalTrials.gov

Summary

The purpose of this study is to see if patients with cancer have a certain amount of genetic mutations in their blood. If certain levels of mutations are found in specific genes, patients may have a condition known as ARCH. The prevalence of ARCH is higher in cancer patients who received prior chemotherapy or radiation. Studying ARCH from your blood samples may also help researchers predict which patients are more likely to be prone to heart disease. Patients who are about to start chemotherapy/radiation, and patients who have completed chemotherapy/radiation will be approached to measure the incidence of ARCH. 5-10mL blood samples will be collected before and after treatment, and if ARCH is detected in a laboratory analysis, another blood sample will be collected. Patients with ARCH will repeat the blood collection yearly, and also be referred to a cardiology clinic for follow up.

Official title: Identification of Patients With Age-Related Clonal Hematopoiesis (ARCH) Among Cancer Survivors.

Key Details

Gender

All

Age Range

60 Years - Any

Study Type

OBSERVATIONAL

Enrollment

2400

Start Date

2019-01-18

Completion Date

2029-12-31

Last Updated

2025-02-03

Healthy Volunteers

Not specified

Conditions

Interventions

OTHER

Monitoring of ARCH variants

Blood samples will be tested for mutations, before patients are given Standard of Care chemotherapy/radiation or after given Standard of Care chemotherapy/radiation. Another testing is done after 3 months and after 1 year if positive for ARCH.

Locations (1)

Princess Margaret Cancer Centre

Toronto, Ontario, Canada