Inclusion Criteria:
* Females and males 18 - 70 years old
* Has single or multiple compartment syndrome of the lower leg that includes the anterior tibial compartment
* Trauma patients with lower extremity CS requiring fasciotomy that can be treated with autologous BM-MNC therapy on day 5-9 post-fasciotomy
* Ability to sign an informed patient consent form
* Access and willingness to complete a standard of care course of rehabilitation therapy and 24 months follow-up evaluations
* Ability to close the fasciotomy wound per physician assessment
* Anterior compartment muscle volume between 100 - 280 cc as determined by MRI/CT
* Within the institutions' clinical reference ranges for HbA1C
* Negative HIV test
· - Non-fracture, closed fracture or compound fracture type I (wound less than 1cm \& compound from within out) (Gustilo-Anderson classification)
* Female subjects must be of non-childbearing potential or must be using adequate contraception
* If female subject is of childbearing potential, subject must have a negative pregnancy test at screening
* Willing and able to adhere to the study schedule
Exclusion Criteria:
* Prior compartment syndrome of same limb;
* Active malignancy or has undergone treatment for a malignancy in the preceding 5 years as indicated in past medical history or self-report if medical records do not accompany subject or are unable to be collected (basal cell carcinoma non-exclusionary);
* HIV positive as indicated by past medical history, self-report, or positive HIV test;
* Diagnosis of Type 1 or Type 2 diabetes with elevated HbA1C consistent with diabetes;(controlled diabetes acceptable, diabetes medication for other diagnosis acceptable)
* Diagnosis of chronic lower extremity vascular disease as diagnosed by current physician diagnosis, indicated in past medical history, or self-report if medical records do not accompany subject or are unable to be collected;
* Patients unable to sign an informed patient consent;
* Anticipated amputation of involved limb;
* Neurological conditions (i.e. spinal cord injury or traumatic brain injury) that may prevent full participation in CS rehabilitation or potentially confound study outcome measures (i.e. balance and gait) per physician discretion
* Current systemic infection;
* Local infection of the involved muscle group;
* Use of ventilator that would preclude rehabilitation protocols;
* Lack of access or unwillingness to complete standard of care course of physical therapy rehabilitation;
* Life expectancy 12 months or less;
* Bone marrow disorders (i.e. leukemia, aplastic anemia, lymphoma) ;
* Inability to close the fasciotomy wound or lower extremity burns that may affect wound closure
* Extensive tissue loss due to debridement resulting in insufficient residual tissue for stem cell administration and subsequent engraftment
* Lower extremity compound fracture type II or III (Gustilo-Anderson classification);
* Anterior tibialis muscle volume less than 100 cc or greater than 280 cc as determined by MRI/CT;
* Evidence of any past or present clinically significant medical condition that would impair wound healing
* History or clinical manifestations of significant renal, hepatic, cardiovascular, metabolic, neurologic, psychiatric, or other condition that would preclude participation in the study as determined by the investigator or the investigator's designee;
* Any reason, considered by the principal investigator or designee, to preclude subject enrollment in the study that might represent a threat to the subject's health or safety.
