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Sub-type Specific Genomic Mutations in sBOTs
Sponsor: Universitair Ziekenhuis Brussel
Summary
The aim of this study is to identify different origin in carcinogenesis between serous borderline ovarian tumors presenting a. without implants, b. with non-invasive implants, c. with invasive implants and d. with micropapillary pattern. The presence of specific mutations could suggest for a more aggressive primary treatment if a higher risk of recurrence can be expected.
Official title: Sub-type Specific Genomic Mutations in Serous Borderline Ovarian Tumors
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
20
Start Date
2017-01
Completion Date
2027-07-30
Last Updated
2026-05-04
Healthy Volunteers
No
Conditions
Interventions
genomic mutations study
Sequencing of the DNA samples extracted from the subgroups 1. serous BOT tissue, 2. serous BOT tissue with non-invasive implants and 3. serous BOT tissue with micropapillary grow pattern will undergo a panel testing for Type 1 genes (small panel 15-40 mutations) AND p53 AND BRCA testing Sequencing of the DNA samples extracted from the serous BOT tissue with invasive implants will undergo a more comprehensive examination (large panel +- 1000 genes checked)
Locations (1)
Universitair Ziekenhuis UZBrussel
Jette, Brussels Capital, Belgium