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Novel 3D Hematological Malignancy Organoid to Study Disease Biology and Chemosensitivity
Sponsor: Wake Forest University Health Sciences
Summary
The objective of this project is to compare chemosensitivity between chemotherapy combinations in bone marrow aspirates using 3D organoid models. The investigators overarching hypothesis is that 3D organoids are ideal to test chemosensitivity in real time, to provide personalized medicine and guidance in the setting of relapsed hematologic malignancy and potentially other cancers.
Official title: Novel 3D Hematological Malignancy Organoid Platform to Study Disease Biology and Perform Chemosensitivity Assays for Patient-Specific Care
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
70
Start Date
2019-05-16
Completion Date
2027-02
Last Updated
2026-03-20
Healthy Volunteers
No
Conditions
Interventions
Ancillary-Correlative - Creation of three-dimensional myeloma organoids using marrow aspirates
Bone marrow aspirates will be collected from participants with hematologic malignancy being evaluated for relapsed disease to create three-dimensional constructs using a three-dimensional bioprinting methodology for automated organoid biofabrication.
Locations (1)
Wake Forest Baptist Comprehensive Cancer Center
Winston-Salem, North Carolina, United States