Clinical Research Directory

Inclusion Criteria * onset at age ≤40 years; * claudication of an extremity; * decreased brachial artery pulse; * \>10 mm Hg difference in systolic blood pressure between arms; * a bruit over the subclavian arteries or the aorta; * angiographic evidence of narrowing or occlusion of the entire aorta, its primary branches, or large arteries in the proximal upper or lower extremities. * Patients should meet at least 3 of the above 6 articles. * Sign the informed consent Exclusion Criteria * autoimmune diseases, such as ANCA-associated vasculitis, systemic lupus erythematosus, Behcet's disease, rheumatoid arthritis, ankylosing spondylitis, etc.; * complicated medical abnormal conditions, un-related with TA but engendering the unpredictable risks, such as severe, progressive, or uncontrollable kidney, liver, blood, gastrointestinal, pulmonary, heart, neuron or others * malignant tumors; * serious acute or chronic infections; * high risk of tuberculosis infection such as clinical, radiological or laboratory evidence of active or occult tuberculosis, or the history of active tuberculosis; * Having received or plan to receive plasma exchange or lymphocyte replacement or immunoabsorption therapy within 1 year. * Preparing to receive an attenuated vaccine during the trial; * Having received or plan to receive an organ transplant; Exit criteria * participants require to withdraw during the study; * participants who believe that they need to withdraw due to clinical adverse events; * Participants can not or does not comply with the requirements of the research protocol;