Clinical Research Directory

Inclusion Criteria: 1. subjects with prior history of clinical ASCVD 2. subjects with primary elevation of LDL cholesterol ≥190 mg/dL 3. subjects with diabetes, age 40 to 75 years, and LDL cholesterol 70 to 189 mg/dL 4. subjects without diabetes, age 40 to 75 years, LDL cholesterol 70 to 189 mg/dL, and with estimated 10-year ASCVD risk ≥7.5%. Exclusion Criteria: 1. history of significant statin-induced rhabdomyolysis or myopathy 2. history of a significant hypersensitivity reaction to rosuvastatin 3. uncontrolled diabetes mellitus (HbA1c \>9%) 4. uncontrolled hypertension (systolic blood pressure \>190 mmHg or diastolic blood pressure \>100 mmHg) 5. current active liver disease (alanine aminotransferase and/or aspartate aminotransferase \>2 times the upper limit of normal) 6. chronic kidney disease (serum creatinine clearance \<30 ml/min) 7. creatine kinase levels \>3 times the upper limit of normal 8. use of prohibited concomitant therapies 9. history of malignancy within the last 5 years 10. women who were pregnant, breast-feeding or of childbearing potential without contraception 11. subjects who would take any medication for purposes other than this trial within 30 days after taking this study's medication.