Clinical Research Directory
Browse clinical research sites, groups, and studies.
Neural Correlates of Sensory Phenomena in Tourette Syndrome
Sponsor: Vanderbilt University Medical Center
Summary
The most pervasive sensory manifestation of TS is sensory over-responsivity (SOR). SOR is defined as excessive behavioral response to commonplace environmental stimuli. SOR is an integral but poorly understood facet of the TS phenotype, one intertwined with core elements of the disorder and worse QOL. This proposal seeks to clarify the mechanistic bases of SOR in TS. Adults with with TS will be recruited 1) to complete a standardized clinical symptom assessment battery and 2) to undergo electroencephalogram (EEG), autonomic, and audio-visual monitoring during tactile and auditory stimuli paradigms, as well as at rest.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2021-07-20
Completion Date
2027-02-28
Last Updated
2026-01-14
Healthy Volunteers
Yes
Interventions
Electroencephalogram (EEG) testing procedure
EEG testing procedure, comprised of somatosensory and auditory event-related potential paradigms, as well as resting state EEG
Autonomic function testing procedure
Autonomic function testing procedure, comprised of electrodes to determine heart rate variability and electrodermal activity (EDA)
Locations (1)
Vanderbilt University Medical Center
Nashville, Tennessee, United States