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ENROLLING BY INVITATION
NCT03914664

Neural Correlates of Sensory Phenomena in Tourette Syndrome

Sponsor: Vanderbilt University Medical Center

View on ClinicalTrials.gov

Summary

The most pervasive sensory manifestation of TS is sensory over-responsivity (SOR). SOR is defined as excessive behavioral response to commonplace environmental stimuli. SOR is an integral but poorly understood facet of the TS phenotype, one intertwined with core elements of the disorder and worse QOL. This proposal seeks to clarify the mechanistic bases of SOR in TS. Adults with with TS will be recruited 1) to complete a standardized clinical symptom assessment battery and 2) to undergo electroencephalogram (EEG), autonomic, and audio-visual monitoring during tactile and auditory stimuli paradigms, as well as at rest.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

50

Start Date

2021-07-20

Completion Date

2027-02-28

Last Updated

2026-01-14

Healthy Volunteers

Yes

Interventions

DIAGNOSTIC_TEST

Electroencephalogram (EEG) testing procedure

EEG testing procedure, comprised of somatosensory and auditory event-related potential paradigms, as well as resting state EEG

DIAGNOSTIC_TEST

Autonomic function testing procedure

Autonomic function testing procedure, comprised of electrodes to determine heart rate variability and electrodermal activity (EDA)

Locations (1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States